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Investigating the effects of three drugs, midazolam, propofol and dexmedetomidine, on hemodynamic changes in cataract surgery patients.

A comparison between the effects of midazolam, propofol, and dexmedethomidine on hemodynamics variation in patients undergoing cataract surgery under local anesthesia

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221020056250N1
Enrollment
110
Registered
2022-12-07
Start date
2022-10-23
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract surgery. Keratopathy (bullous aphakic) following cataract surgery

Interventions

Intervention 1: The first intervention group: midazolam drug with a sedative dose of 100-25 µg/kg is injected as a intravenous bolus once before surgery for one minute. Intervention 2: The second inte

Sponsors

Gorgan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for surgery ASA class 2 and 3 patients patients in the age range of 18-90 years

Exclusion criteria

Exclusion criteria: Patients aged less than 18 years and more than 90 years The patient is pregnant

Design outcomes

Primary

MeasureTime frame
Blood pressure measurement. Timepoint: Blood pressure before the injection of sedative drugs in each group, then 3 minutes after the injection of sedative drugs, and after that, the result every 5 minutes until the end of the surgery, and finally after delivery to recovery, every 15 minutes for an hour. They are measured so that the patient is delivered to the desired department. Method of measurement: The blood pressure of all patients will be taken by an automatic sphygmomanometer from the arm opposite to the surgical site.;Arterial blood oxygen. Timepoint: Blood pressure before the injection of sedative drugs in each group, then 3 minutes after the injection of sedative drugs, and after that, the result every 5 minutes until the end of the surgery, and finally after delivery to recovery, every 15 minutes for an hour. They are measured so that the patient is delivered to the desired department. Method of measurement: During the operation, all patients are examined for arterial blood oxygen saturation percentage while receiving 6 liters of oxygen per minute, and this measurement is done with a pulse oximeter device.;Nausea and vomiting. Timepoint: Blood pressure before the injection of sedative drugs in each group, then 3 minutes after the injection of sedative drugs, and after that, the result every 5 minutes until the end of the surgery, and finally after delivery to recovery, every 15 minutes for an hour. They are measured so that the patient is delivered to the desired department. Method of measurement: Vomiting and nausea of the patient during the operation, if observed, is recorded by mentioning the number.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Akbari

Gorgan University of Medical Sciences

mr.akbari.1344@gmail.com+98 58 3222 2683

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026