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Comparison of lisdexamphetamine and and methylphenidate in adult ADHD

Evaluation of efficacy of treatment with lisdexamphetamine (vyas) in comparison with extended release methylphenidate (sandoz) on improving the quality of life and executive function of adults with attention deficit hyperactivity disorder : an open-lable randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221018056238N1
Enrollment
56
Registered
2022-11-21
Start date
2022-10-30
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADULT ADHD. Attention-deficit hyperactivity disorders

Interventions

Intervention 1: The first group that receives Lisdexamfetamine (Vyas) for the treatment of ADHD, which will be continued for 8 weeks for each patient. The low dose of drug will start based on the inte

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to No maximum

Inclusion criteria

Inclusion criteria: Age more than 16 years Diagnosis of adult attention deficit hyperactive disorder based on DSM-5 Diagnosis of adult attention deficit hyperactive disorder based on DIVA-5

Exclusion criteria

Exclusion criteria: Alcohol and other substance us History of Bipolar or psychotic disorders Other psychiatric disorders such as MDD or Autism spectrum disorder Pregnancy or Lactation hypersensitivity to drugs used in this study Neurologic disorders or severe Hepatic or Renal disease BMI less than 18 Dependency to drugs ex. Benzodiazepines MDMA and other substances History of not responding to stimulants Use of any other drug with effects on CNS

Design outcomes

Primary

MeasureTime frame
Primary outcome measure includes changes in scores of BDEFS and WHOQOL scores from the beginning to the end of study. Timepoint: before intervention then 2,4,8 weeks after intervention. Method of measurement: Questioner of Barkley deficits in executive functioning scale for adults , WHO Questioner of quality of life , Clinical global impression GCI Questioner.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzin Aivazziaei

Tehran University of Medical Sciences

a-aziaei@razi.tums.ac.ir+98 21 5541 9151

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026