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Investigating the effectiveness of mouthwash containing green tea extract and pomegranate peel, with and without zinc, compared to 0.12% chlorhexidine mouthwash on gingivitis in patients with gingivitis or mild chronic periodontitis: a double-blind randomized clinical trial

Investigating the effectiveness of mouthwash containing green tea extract and pomegranate peel, with and without zinc, compared to 0.12% chlorhexidine mouthwash on gingivitis in patients with gingivitis or mild chronic periodontitis: a double-blind randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221017056214N1
Enrollment
105
Registered
2022-11-02
Start date
2022-08-01
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild chronic gingivitis or periodontitis. Chronic gingivitis, plaque induced

Interventions

Intervention 1: Intervention group: Intervention group: patients in a questionnaire based on the block sequence list, in one of groups A (mouthwash containing pomegranate peel extract and green tea, w
The people of this group were given green tea extract - pomegranate peel - zinc mouthwash. Group B was the same as the second intervention group, this group was given green tea extract-pomegranate sk

Sponsors

Rasht University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Having at least 20 natural teeth Suffering from gingivitis or mild chronic periodontitis Loss of clinical connections less than or equal to 2 mm Probe depth less than or equal to 3 mm will be included in the study

Exclusion criteria

Exclusion criteria: Allergic reaction to pomegranate Systemic diseases such as diabetes mellitus Pregnant and lactating women Cigarette or tobacco user Taking antibiotics or non-steroidal anti-inflammatory drugs in the 6 months before the study History of receiving periodontal interventions in the 6 months before the study

Design outcomes

Primary

MeasureTime frame
Measuring the PBI index of the gingival groove is probed by using the Michigan O probe with Williams marking, in walking mode. 30 seconds after probing the gingival groove, the presence or absence of bleeding in 3 points on the buccal surface (mesiobuccal, midbuccal and distobuccal) and 3 points on the lingual surface (mesiolingual, midlingual and distolingual) will be checked and recorded. The number of bleeding areas will be calculated and this index will be reported as the percentage of bleeding dental surfaces compared to the total dental surfaces.MGI index of inflammation, color change and gum contour change will be checked in 6 points around all teeth. 3 points on the buccal level (mesiobuccal, midbuccal and distobuccal) and 3 points on the lingual level (mesiolingual, midlingual and distolingual) are evaluated and each one will be given a score from 0 to 4. So that score 0 is without inflammation; score 1, the presence of mild inflammation with a slight change in color and contour in parts of the gum; score 2, the presence of mild inflammation in the entire gum; Score 3 means moderate inflammation and score 4 means severe inflammation. The average of the obtained numbers will be calculated and reported. To measure the PI index, patients are asked to chew Fushin tablets for 60 seconds and then rinse their mouths. Stained surfaces will be considered as positive surfaces. Unpainted surfaces are considered as negative surfaces. Staining or not staining will be evaluated at 4 points including midbuccal, mesial papillae, midlingual and distal papillae. This index is reported as the percentage of stained areas compared to the total tooth surfaces. Timepoint: Indicators are measured 2 weeks after using the mouthwash. Method of measurement: MGI index and PI index are clinically evaluated based on the indices. 30 After exploring the gingival groove, the presence or absence of presence is checked.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBardia vadiati

Rasht University of Medical Sciences

Dr.bardia_vad@yahoo.com0981333486406

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026