Comparing curcumin mediated photodynamic therapy and topical corticosteroid in tratment of oral OLP

Comparing the therapeutic effects of curcumin mediated photodynamic therapy and topical corticosteroid in tratment of erosive OLP

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221016056202N1

Enrollment

Registered

2022-10-23

Start date

2022-11-06

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral lichen planus. Lichen planus

Interventions

Intervention 1: Intervention group: In each photodynamic therapy session Sinanomin 1%( Topical gel contains %1 curcumin as nanoliposome from Exir Nanosina company will applied for 10 minutes in the

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Clinical diagnosis of OLP by 2 oral medicine specialists Presence of bilateral errosive symptomatic lesions Patients willing to actively participate in the study Patients that are capable of performing the exact instructions of the treatment protocol.

Exclusion criteria

Exclusion criteria: Age < 18 years Pregnancy or lactation Uncontrolled systemic diseases (hepatopathies, coagulopathies,auto immune or haematological diseases) History of allergic reactions to the active ingredient (curcumin) used in the clinical trial Presence of histological signs of dysplasia in the biopsy specimen Evidence of lichenoid lesions due to specific causes (dental materials, use of drugs inducing lichenoid reactions such as hypertensive or diabetic medications, etc.) Smokers or heavy drinkers of alcohol. Diabetic patients Patients with photosensivity Lichenoid reaction

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: visual analogue scale.;Size of lesion. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: Digital caliper.;Clinical manifestations of inflammation. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: Thongprasom sign scoring.;Clinical Efficacy of treatment. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: REU.	—

Measure

Time frame

Pain. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: visual analogue scale.;Size of lesion. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: Digital caliper.;Clinical manifestations of inflammation. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: Thongprasom sign scoring.;Clinical Efficacy of treatment. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: REU.

—

Secondary

Measure	Time frame
Allergy to curcumin. Timepoint: days 1 and 3 and 5. Method of measurement: Observe the side effects of increased sensitivity.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanieh Farahmand

Shiraz University of Medical Sciences

h_farahmand@sums.ac.ir+98 917 104 5288

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026