In vitro drug-free activation (IVA) of the ovarian cortex and its re-transplantation in infertile women with reduced ovarian reserve

In vitro drug-free activation of the ovarian cortex and its re-transplantation in infertile women with reduced ovarian reserve

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221016056198N3

Enrollment

Registered

2023-03-31

Start date

2023-05-01

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertile women with reduced ovarian reserve. Female infertility

Interventions

Intervention group: Infertile women suffering from reduced ovarian reserve are candidates for ovarian cortex activation during laparoscopic surgery.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients with age less than 40 years had decreased ovarian reserve based on POSEIDON group 3 and 4 criteria AMH less than 1 mg/dl Fsh less than 10 with a history of at least one failed stimulation cycle resulting in the inability to retrieve oocyte

Exclusion criteria

Exclusion criteria: male factor infertility positive history of hydrosalpinx anatomical uterine disorders endocrine disease

Design outcomes

Primary

Measure	Time frame
The count of retrieved oocytes. Timepoint: 3 months after IVA. Method of measurement: microscopic.;The count of metaphase II oocytes. Timepoint: 3 months after IVA. Method of measurement: microscopic.	—

Secondary

Measure	Time frame
Quantity of embryos transferred. Timepoint: 6 day after stimulation. Method of measurement: microscopic.;Implantation rate. Timepoint: 5 weeks after transfer. Method of measurement: tvs sonography.;Clinical pregnancy rate. Timepoint: 5 weeks after transfer. Method of measurement: tvs sonography.;Number of embryos transferred. Timepoint: 6 day after stimulation. Method of measurement: microscopic.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazanin Hajizadeh

Shahid Beheshti University of Medical Sciences

Hajizadeh.nazanin94@yahoo.com+98 21 2243 2600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026