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bismuth- containing quadruple and high-dose dual therapy in eradication of Helicobacter pylori infection

Comparison of high-dose dual therapy and bismuth- containing quadruple therapy as a standard first line treatment in eradication of Helicobacter pylori infection

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221016056190N1
Enrollment
200
Registered
2023-01-15
Start date
2021-03-21
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eradication of Helicobacter pylori infection. ?????????? ?????? ?? ????? ???? ?????? ?? ?? ?? ??? ??? ???? ???? ???? ?? ???

Interventions

Intervention 1: Intervention group: The first intervention group was treated with four standard medicines containing bismuth, including amoxicillin (1 gram 30 minutes after breakfast and dinner), pant

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients with chronic gastritis with or without improved PUD caused by Helicobacter pylori Helicobacter pylori (+) determined by any of the rapid urease test and histopathology, urease breath test, fecal antigen test Patients who have not received Helicobacter pylori eradication treatment

Exclusion criteria

Exclusion criteria: Allergy to the drugs used in the study Use of PPIs, H2 receptor antagonists, antibiotics, bismuth or probiotics in the last 4 weeks before entering the study Smoking and alcohol abuse The presence of underlying disease or conditions such as liver disease, cardiovascular disease, lung disease, metabolic disease, or malignant tumor that may affect the study Pregnant or lactating female patients Performing esophageal or gastric surgery procedures in the past Incomplete follow-up or low acceptance capacity of patients in treatment during the study

Design outcomes

Primary

MeasureTime frame
Eradication of Helicobacter pylori infection. Timepoint: 4 weeks after receiving two treatment regimens, the eradication rate of Helicobacter pylori in two groups is compared. Method of measurement: Laboratory method of testing Helicobacter pylori antigen in stool.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Abbasi

Shahid Beheshti University of Medical Sciences

Abasimaryam1989@yahoo.com+98 21 8827 9679

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026