Evaluation of the preoperative effect of Mirtazapine administration on reducing postoperative pain, in hospitals affiliated with Islamic Azad University of Tehran in 2023

76 patients who are candidates for surgery in hospitals affiliated with Islamic Azad University of Tehran are randomly divided into two groups. One hour before surgery, Mirtazapine will be given to the intervention group and placebo to the control group. After transferring the patients to the ward, the pain level of the patients is measured serially. We want to evaluate the preoperative effect of Mirtazapine administration on reducing postoperative pain (pain severity and duration of pain relief).

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221015056178N1

Enrollment

Registered

2023-08-08

Start date

2023-08-12

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain.

Interventions

Intervention 1: Intervention group: Mirtazapine. Intervention 2: Control group: B-Complex.

Eligibility

Sex/Gender

All

Age

25 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for surgery Insensitivity to Mirtazapine Age between 25 and 50 years BMI between 20 and 25 ASA one or two Patient consent to conduct a clinical trial

Exclusion criteria

Exclusion criteria: Surgeries greater than an hour Emergency surgeries Pregnant women or the possibility of pregnancy Diabetic, cardiac, pulmonary and neurological patients Drug addiction

Design outcomes

Primary

Measure	Time frame
Severity of postoperative pain. Timepoint: 2, 6 and 12 hours after leaving the operating room. Method of measurement: Visual Analogue Scale (facial experience).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMobina Niazi Nasihati

Islamic Azad University

Niazi.mobina@yahoo.com+98 21 2230 8901

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026