Mupirocin ointment effect on Polyposis recurrence after Sinus surgery

Efficacy of Mupirocin Ointment into Nostril on polyposis reccurence Following Functional endoscopic sinus surgery (FESS) in Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221013056165N1

Enrollment

Registered

2024-05-05

Start date

2020-03-20

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Rhinosinusitis with Nasal Polyposis. Chronic sinusitis

Interventions

Intervention 1: Intervention group: Mupirocin-Najo 2%, topical ointment -made by Iran Najo pharmaceutical company, Tehran, Iran- was prescribed twice daily for six months from the time of primary sur

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with CRSwNP candidate for surgery Lund-Mackay scores and Lund-kennedy scores were almost same at both sides of the nose and sinuses

Exclusion criteria

Exclusion criteria: Nasal polyposis due to neoplasm, autoimmune diseases, Fungal rhinosinusitis and ect except Chronic Rhinosinusitis with Nasal Polyposis Patients with Lund-Mackay and Lund-Kennedy scores were significantly different at both sides of the nose and sinuses

Design outcomes

Primary

Measure	Time frame
Lund Mackay radiologic score. Timepoint: At the beginning of the study (before the start of the intervention), 6 months after using the ointment. Method of measurement: Lund Mackay radiologic scoring system.;Lund Kennedy endoscopic score. Timepoint: At the beginning of the study (before the start of the intervention), 6 months after using the ointment. Method of measurement: Lund Kennedy endoscopic scoring system.	—

Measure

Time frame

Lund Mackay radiologic score. Timepoint: At the beginning of the study (before the start of the intervention), 6 months after using the ointment. Method of measurement: Lund Mackay radiologic scoring system.;Lund Kennedy endoscopic score. Timepoint: At the beginning of the study (before the start of the intervention), 6 months after using the ointment. Method of measurement: Lund Kennedy endoscopic scoring system.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Mohsenian

Iran University of Medical Sciences

PR@iums.ac.ir+98 21 8670 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026