Allergic rhinitis. Allergic rhinitis, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Patients will receive sweet pomegranate juice concentrate (ml/day 50) for 2 months, in addition to taking antihistamine and corticosteroid drugs. Pomegranate concen
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Allergic rhinitis patients Patients who have been treated with standard drugs including antihistamines and corticosteroids for at least 4 weeks and have had a poor or no response to these treatments are included in the study.
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding Patients with non-allergic rhinitis Patients with systemic diseases Use of herbal supplements with antioxidant properties Liver dysfunction (LFT>3ULN) Kidney dysfunction (GFR<60 ml/kg/min) Thyroid disorders (based on thyroid function test) Epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determining the severity of clinical symptoms of patients (including sneezing, an itchy nose, a runny or blocked nose, itchy, red and watery eyes, a cough, the roof of mouth being itchy). Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Using of Sino-Nasal Test 20 (SNOT-20). | — |
Secondary
| Measure | Time frame |
|---|---|
| The level of specific IgE. Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Collection of blood samples from patients.;Th1/Th2 cytokines. Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Collection of blood samples from patients.;Determination of interferon (IFN)-? concentration. Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Collection of blood samples from patients.;Determination of interleukin IL-4 and IL-5 concentrations. Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Collection of blood samples from patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mahdi Bakhshaee
Mashhad University of Medical Sciences
Outcome results
None listed