Comparison of the Effect of Stem Cells and Bone Grafting in the Treatment of Bone Non-union

Comparison of the Results of Scaphoid Non-union Treatment with Two Methods "Internal Fixation + Autologous Bone Graft" and "Internal Fixation + Allogenic Umbilical Cord Mesenchymal Stem Cells" in Patients Referred to Dr. Shariati Hospital in 2023

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221009056121N1

Enrollment

Registered

2022-12-10

Start date

2022-12-22

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Scaphoid Non-union. Unspecified fracture of navicular [scaphoid] bone of unspecified wrist, subsequent encounter for fracture with nonunion

Interventions

Intervention 1: Intervention group: nonunion of the scaphoid bone undergoes internal fixation and allogeneic mesenchymal stem cells of umbilical cord origin implanted in fibrin gel are used to induce

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Having Scaphoid Non-union At Least 3 Months Between Fracture and Surgical Treatment Consent of the Patient to Participate in the Study

Exclusion criteria

Exclusion criteria: Previous Surgery on the Wrist Wrist Osteoarthritis Presence of Accompanying Injury (Fracture in Other Bones of the Wrist)

Design outcomes

Primary

Measure	Time frame
Union of Scaphoid Bone. Timepoint: 3, 6, 9, 12, 24, and 48 Months After Surgery. Method of measurement: Antero-posterior and Lateral Radiography of the Wrist.	—

Secondary

Measure	Time frame
Pain. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Visual Analogue Scale.;Function. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Qiuck-DASH (Disabilities of the Arm, Shoulder, and Hand score).;Time to Union. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Week.;Grip Strength. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Jamar Dynamometer.;Wrist Range of Motion. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Clinical Examination (Degree).;Surgical Complications. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Clinical Examination.;Satisfaction with Surgery. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Ask the Patient.	—

Measure

Time frame

Pain. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Visual Analogue Scale.;Function. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Qiuck-DASH (Disabilities of the Arm, Shoulder, and Hand score).;Time to Union. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Week.;Grip Strength. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Jamar Dynamometer.;Wrist Range of Motion. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Clinical Examination (Degree).;Surgical Complications. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Clinical Examination.;Satisfaction with Surgery. Timepoint: 3, 6, 9, 12, 24, 48 and 96 Months After Surgery. Method of measurement: Ask the Patient.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Najafi

Tehran University of Medical Sciences

ehsan.n.6384@gmail.com+98 21 8490 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026