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The effect of royal jelly on inflammatory mediators in multiple sclerosis patients

Evaluation of the effect of royal jelly consumption on inflammatory mediators including interleukin-1-beta, interleukin-6, interferon-gamma and tumor necrosis factor in patients with multiple sclerosis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20221002056071N1
Enrollment
60
Registered
2022-12-29
Start date
2023-01-10
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple sclerosis. Demyelinating diseases of the central nervous system

Interventions

Intervention 1: Intervention group:The case group (30 MS patients) received sixty 500mg capsules of royal jelly prepared by Rodin Food Industry Company and they were asked to eat one capsule daily bef

Sponsors

Dezfoul University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria of participants:: Patients' subtype of M.S should be the "relapsing-remitting MS" (RRMS). The patient's age should be 20- 45 years old and all of them treated with interferon for at least 6 months.

Exclusion criteria

Exclusion criteria: Patients with anemia, chronic heart disease, lung disease, diabetic Mellitus, autoimmune diseases such as rheumatoid arthritis, SLE, liver diseases, and a history of asthma and allergies. Patients are treated with corticosteroids or ACTH drugs, or consumption of supplements.

Design outcomes

Primary

MeasureTime frame
Expanded Disability Status Scale. Timepoint: Study of "Expanded Disability Status Scale" at the beginning of the study and on day 60 after the use of Royal Jelly. Method of measurement: Scoring from zero (best condition) to 10 (death due to MS) according to the neurologist.

Secondary

MeasureTime frame
The amount of change in the amount of inflammatory cytokines. Timepoint: Investigating the level of inflammatory cytokines at the beginning of the study and on the 60th day after the end of using royal jelly. Method of measurement: Eliza method.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahin Behzadifard

Dezfoul University of Medical Sciences

mahinbehzadi2020@gmail.com+98 66 4242 9533

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026