Comparing the effects of ovarian stimulation in infertile patients

Comparison of ovarian stimulation in proliferative and luteal phases in an ovarian cycle (DuoStim method) in patients with poor ovarian response

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20221001056068N1

Enrollment

Registered

2022-11-22

Start date

2022-10-02

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Female infertility

Interventions

Intervention group: In the DuoStim method, ovarian stimulation is performed in both ovarian phases. From the third day of menstruation, all poor ovarian response patients who are candidates for in vit

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Women who are known as patients with poor response to ovulation stimulation according to POSEIDON 3 and 4 diagnostic criteria and will undergo the necessary treatment protocols for IVF/ICSI.

Exclusion criteria

Exclusion criteria: Azoospermia confirmed via a semen analysis History of surgery on the uterus Severe endometriosis through history and ultrasound findings Hydrosalpinx by ultrasound or hysterosalpingography Endocrine disorders such as diabetes, thyroid through blood biochemistry test Body Mass Index (BMI)>30 History of hysteroscopy History of recurrent abortions in the history History of recurrent failure of implantation (more than or equal to 3 times )

Design outcomes

Primary

Measure	Time frame
The overall percentage of fertility in the proliferative phase and the luteal phase. Timepoint: Day 14 and day 28 after the start of ovarian stimulation. Method of measurement: optical microscope.	—

Secondary

Measure	Time frame
The average number of metaphase 2 oocytes after ovulation in the proliferative phase and the luteal phase. Timepoint: Day 14 and day 28 after the start of ovarian stimulation. Method of measurement: optical microscope.;The average number of oocytes after ovulation in proliferative phase and luteal phase. Timepoint: Day 14 and day 28 after the start of ovarian stimulation. Method of measurement: optical microscope.;The average of number of 3-day-old embryos obtained after in vitro fertilization in the proliferative phase and the luteal phase. Timepoint: Day 17and day 31after the start of ovarian stimulation. Method of measurement: optical microscope.;The average quality of 3-day-old embryos obtained in proliferative phase and luteal phase. Timepoint: Day 17and day 31after the start of ovarian stimulation. Method of measurement: optical microscope.	—

Measure

Time frame

The average number of metaphase 2 oocytes after ovulation in the proliferative phase and the luteal phase. Timepoint: Day 14 and day 28 after the start of ovarian stimulation. Method of measurement: optical microscope.;The average number of oocytes after ovulation in proliferative phase and luteal phase. Timepoint: Day 14 and day 28 after the start of ovarian stimulation. Method of measurement: optical microscope.;The average of number of 3-day-old embryos obtained after in vitro fertilization in the proliferative phase and the luteal phase. Timepoint: Day 17and day 31after the start of ovarian stimulation. Method of measurement: optical microscope.;The average quality of 3-day-old embryos obtained in proliferative phase and luteal phase. Timepoint: Day 17and day 31after the start of ovarian stimulation. Method of measurement: optical microscope.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSafa Salehi

Esfahan University of Medical Sciences

mina.salehi123321@gmail.com009877333535655

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 9, 2026