Investigating the effects of intermittent fasting in improving the conditions of patients with rheumatoid arthritis

The Evaluation of the effects of intermittent fasting diet on metabolic parameters, antioxidant indices and lipid peroxidation in overweight and obese menopause women with rheumatoid arthritis: a clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220929056058N1

Enrollment

Registered

2024-01-15

Start date

2023-12-22

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis. Rheumatoid arthritis with rheumatoid factor

Interventions

Intervention 1: Intervention group: The people of the intervention group have an intermittent fasting diet of the type (16:8) in which people are only allowed to receive water and non-energy drinks, t

Eligibility

Sex/Gender

Female

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Women Body mass index 25-35 kg/m2 Age range between 50 and 70 years Menopause Menopause Diagnosed with rheumatoid arthritis by a rheumatologist for more than 6 months Moderate to low rheumatoid arthritis disease activity (i.e. disease activity score <5.1) Following a stable drug regimen for 3 months before the intervention Not receiving non-steroidal anti-inflammatory drugs (NSAIDs) Willingness to cooperate

Exclusion criteria

Exclusion criteria: Consumption of alcohol Suffering from other autoimmune diseases , kidney diseases, pancreatitis, gallstones, cancer Pregnancy and breastfeeding Following a special diet in the last three months Changing the medication regimen from 3 months

Design outcomes

Primary

Measure	Time frame
Malondialdehyde. Timepoint: At the beginning and end of the study (after 8 weeks (56 days)). Method of measurement: Elisa Method.;In this study, HAQ score is considered as the primary outcome. Timepoint: Investigating the effects of clinical symptoms, inflammation and oxidative stress at the beginning of the study (before the start of the intervention) and 8 weeks after the start of the intermittent fasting diet in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Questionnaire for health assessment-disability index: In order to evaluate the performance of patients, it will be completed by the project manager at the beginning and end of the study, and by asking the patients.;Symptoms of rheumatoid arthritis. Timepoint: The effect of intermittent fasting on the symptoms of rheumatoid arthritis at the beginning of the study (before the intervention) and 8 weeks after the intervention in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Questionnaire to evaluate the degree of swelling and tenderness of joints in rheumatoid arthritis patients, questionnaire of perceived visual pain of the patient, questionnaire of health-disability index, questionnaire to evaluate the level of disease activity by the patient, questionnaire to evaluate the level of disease activity by the researcher, questionnaire to evaluate morning stiffness.;Fasting blood sugar. Timepoint: At the beginning and end of the study (after 8 weeks (56 days)). Method of measurement: Glucose oxidase enzymatic method using commercial kits of Pars Azmoon company in terms of (mg/dL.;Total cholesterol. Timepoint: At the beginning and end of the study (after 8 weeks (56 days)). Method of measurement: Measurement of total cholesterol level using Pars Azmoon kits and auto analyzer.;Triglyceride. Timepoint: At the beginning and end of the study (after 8 weeks (56 days)). Method of measurement: Measurement of triglyceride level using	—

Measure

Time frame

Malondialdehyde. Timepoint: At the beginning and end of the study (after 8 weeks (56 days)). Method of measurement: Elisa Method.;In this study, HAQ score is considered as the primary outcome. Timepoint: Investigating the effects of clinical symptoms, inflammation and oxidative stress at the beginning of the study (before the start of the intervention) and 8 weeks after the start of the intermittent fasting diet in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Questionnaire for health assessment-disability index: In order to evaluate the performance of patients, it will be completed by the project manager at the beginning and end of the study, and by asking the patients.;Symptoms of rheumatoid arthritis. Timepoint: The effect of intermittent fasting on the symptoms of rheumatoid arthritis at the beginning of the study (before the intervention) and 8 weeks after the intervention in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Questionnaire to evaluate the degree of swelling and tenderness of joints in rheumatoid arthritis patients, questionnaire of perceived visual pain of the patient, questionnaire of health-disability index, questionnaire to evaluate the level of disease activity by the patient, questionnaire to evaluate the level of disease activity by the researcher, questionnaire to evaluate morning stiffness.;Fasting blood sugar. Timepoint: At the beginning and end of the study (after 8 weeks (56 days)). Method of measurement: Glucose oxidase enzymatic method using commercial kits of Pars Azmoon company in terms of (mg/dL.;Total cholesterol. Timepoint: At the beginning and end of the study (after 8 weeks (56 days)). Method of measurement: Measurement of total cholesterol level using Pars Azmoon kits and auto analyzer.;Triglyceride. Timepoint: At the beginning and end of the study (after 8 weeks (56 days)). Method of measurement: Measurement of triglyceride level using

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAryan tavakoli

Tehran University of Medical Sciences

aryantavakoli199675@gmail.com+98 21 8895 5975

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026