Diabetic foot ulcer. Personal history of diabetic foot ulcer
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group will receive 600 mg N-acetyl cysteine orally every 12 hours for 14 days in addition to routine treatments. Intervention 2: Contro
Sponsors
Oroumia University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age above 18 years Grade 3 or 4 diabetic foot ulcer according to Wagner criteria
Exclusion criteria
Exclusion criteria: Allergy to N-Acetyl cysteine and sulfur products Pregnancy and breastfeeding Other causes of ulcers except diabetes include trauma and others A generated- ulcers skin disease Impossibility of taking tablets orally Patients treated with chemotherapy or radiotherapy drugs Taking drugs such as: corticosteroids at a minimum dose equivalent to 40 milligrams of prednisolone, mycophenolate, cyclosporine, tacrolimus, rituximab Hospitalized for a diabetic foot ulcer in the last month and receiving injection antibiotic treatment Stenosis and severe cramping of the lower limbs vessels based on vascular sonography Chronic alcohol consumption of more than 250 cc daily
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound size. Timepoint: Before and 14 days after the intervention. Method of measurement: Wound area in cm2 based on imaging.;Wound Number. Timepoint: Before and 14 days after the intervention. Method of measurement: Clinical examination.;Healing time. Timepoint: After intervention. Method of measurement: Days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hospitalization. Timepoint: After intervention. Method of measurement: Days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Laya Hooshmand
Oroumia University of Medical Sciences
Outcome results
None listed