Investigating the effect of methylphenidate on increasing the level of consciousness in patients with hypoxic ischemic encephalopathy

Investigating the effect of methylphenidate on increasing the level of consciousness of patients with hypoxic ischemic encephalopathy in the special care departments of Bo Ali Qazvin Hospital during one year.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220924056025N1

Enrollment

Registered

2022-10-09

Start date

2022-11-21

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypoxic ischemic encephalopathy. Hypoxic ischemic encephalopathy [HIE]

Interventions

Intervention 1: Intervention group: this group receives 10 mg methylphenidate tablets once a day in the morning until the day the patient stays in the ICU (maximum one month) in the form of gavage. In

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients hospitalized in the intensive care unit with the diagnosis of HIE hypoxic ischemic encephalopathy, Aged between 18 and 65 years Both sexes (male and female) With some degree of reduced level of consciousness.

Exclusion criteria

Exclusion criteria: Patients with a history of epilepsy Patients with high blood pressure that is newly discovered and not treated or controlled Patients with Cardiac ischemia and arrhythmia that are newly discovered and not treated or controlled, Patients with deafness Patients with rapid changes in vital signs and unstable hemodynamics Patients with multiple organ failure Patients with hyperthyroidism pregnancy Drug addiction Secondary surgery Reluctance to attend the investigation based on the opinion of the patient's legal guardian

Design outcomes

Primary

Measure	Time frame
Average level of consciousness based on 4 Score criteria. Timepoint: Every three days for a month. Method of measurement: Criterion 4 Score in ICU.	—

Secondary

Measure	Time frame
Average biological indicators of systole and diastole blood pressure. Timepoint: Every three days for a maximum of one month. Method of measurement: Recording of ICU patient monitoring every three days for a maximum of one month.;Average biological index of arterial oxygen saturation percentage. Timepoint: Every three days for a maximum of one month. Method of measurement: Recording of ICU patient monitoring every three days for a maximum of one month.;Average biological index of heart rate. Timepoint: Every three days for a maximum of one month. Method of measurement: Recording of ICU patient monitoring every three days for a maximum of one month.	—

Measure

Time frame

Average biological indicators of systole and diastole blood pressure. Timepoint: Every three days for a maximum of one month. Method of measurement: Recording of ICU patient monitoring every three days for a maximum of one month.;Average biological index of arterial oxygen saturation percentage. Timepoint: Every three days for a maximum of one month. Method of measurement: Recording of ICU patient monitoring every three days for a maximum of one month.;Average biological index of heart rate. Timepoint: Every three days for a maximum of one month. Method of measurement: Recording of ICU patient monitoring every three days for a maximum of one month.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKian Abed Khorasani

Qazvin University of Medical Sciences

kianabed2495@gmail.com+98 28 3333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026