Effect of grape seed extract (GSE) supplementation on serum levels of androgens, gonadotropins and high sensitivity c-reactive protein in women with polycystic ovary syndrome (PCOS)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220921056011N1

Enrollment

Registered

2022-10-20

Start date

2022-10-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic Ovary Syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: They take a daily supplement of 250 mg of grape seed extract (GSE) for 8 weeks. Intervention 2: Control group: They take a placebo supplement daily for 8 weeks.

Eligibility

Sex/Gender

Female

Age

25 Years to 55 Years

Inclusion criteria

Inclusion criteria: Age 25 to pre-menopause BMI<=30 Diagnosis of PCOS based on the Rotterdam criteria and the diagnosis of a gynecologist

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Luteinizing Hormone (LH). Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Follicle-Stimulating Hormone (FSH). Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Fasting insulin. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Homeostatic Model Assessment for Insulin Resistance. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: Formula.;Fasting blood sugar. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Body mass index. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ?????.;Waist-Hip Ratio (WHR). Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: Meter.;Testosterone. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Prolactin. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.	—

Measure

Time frame

Luteinizing Hormone (LH). Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Follicle-Stimulating Hormone (FSH). Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Fasting insulin. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Homeostatic Model Assessment for Insulin Resistance. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: Formula.;Fasting blood sugar. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Body mass index. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ?????.;Waist-Hip Ratio (WHR). Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: Meter.;Testosterone. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.;Prolactin. Timepoint: before the start of the intervention and 8 weeks after taking the supplement. Method of measurement: ELISA kit.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzie Zilaiee

Ahvaz University of Medical Sciences

marziezilae67@gmail.com+98 61 3311 2713

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026