A comparative assessment of Streptococcus mutans population between conventional composites and composites containing bioactive glass in fixed orthodontic patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220912055949N1

Enrollment

Registered

2023-01-30

Start date

2023-02-20

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Streptococcus mutans accumulation around dental brackets. Condition 2: Composite containing bioactive glass.

Interventions

Intervention 1: Intervention group: Bracket bonding using composite containing BAG (TransbondXT adhesive containing BAG). Intervention 2: Control group: Bracket bonding using conventional composite (T

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Patients who need fixed orthodontic treatment. Patients whose upper second premolar teeth are without macroscopic cracks, caries or enamel hypoplasia. Patients who do not have any dental caries.

Exclusion criteria

Exclusion criteria: Patients with systemic diseases Patients with drug-related xerostomia Patients with periodontal diseases Patients whose upper second premolar bracket is detached during treatment.

Design outcomes

Primary

Measure	Time frame
Accumulation of Streptococcus mutans around the brackets of upper premolar teeth. Timepoint: At the beginning of the study (before the start of the intervention), 3 and 6 months after the bonding of brackets. Method of measurement: Sampling is done using a sterile swab. The swab is transferred to a micro tube containing 200 microliters of sterile phosphate buffer. The micro tube is immediately transferred to the microbiology laboratory at a temperature of 4 degrees Celsius. 100 microliters of each sample is cultured on Mitis salivarius agar culture medium. In this study, glycosyl transferase-1 (gtfb-1) gene sequence will be used and with the help of this technique, the amount of Streptococcus mutans accumulation will be measured and compared.	—

Measure

Time frame

Accumulation of Streptococcus mutans around the brackets of upper premolar teeth. Timepoint: At the beginning of the study (before the start of the intervention), 3 and 6 months after the bonding of brackets. Method of measurement: Sampling is done using a sterile swab. The swab is transferred to a micro tube containing 200 microliters of sterile phosphate buffer. The micro tube is immediately transferred to the microbiology laboratory at a temperature of 4 degrees Celsius. 100 microliters of each sample is cultured on Mitis salivarius agar culture medium. In this study, glycosyl transferase-1 (gtfb-1) gene sequence will be used and with the help of this technique, the amount of Streptococcus mutans accumulation will be measured and compared.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Zolfigol

Kerman University of Medical Sciences

s_zolfigol@kmu.ac.ir+98 34 3211 9021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026