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Comparing the effectiveness of estradiol administration on endometrial thickness and pregnancy outcome in infertile women applying for frozen embryo transfer

Investigating the effect of estradiol administration duration on pregnancy outcomes of frozen embryo transfer cycles: a double-blind randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220906055898N1
Enrollment
219
Registered
2022-09-28
Start date
2022-09-22
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: All patients are given oral estradiol at a dose of 4 to 6 mg from the second or third day of the menstrual cycle, and after a week, the patients return for the firs
If the thickness of the endometrium is 7 and above, and suitable, they are divided into three groups in the form of two blind strains. Intervention 2: Intervention group: In the first intervention gro

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: • Patients under 45 years of age • Normal BMI • Patients with at least two good quality embryos for transfer • Patients with a healthy uterine cavity confirmed by hysterosalpingograph and hysteroscope or saline ultrasound

Exclusion criteria

Exclusion criteria: Patients with Uncontrolled Chronic Disease Patients with Donated Ovum or Embryos Patients with surrogacy Patients who Could Not Achieve an Endometrial Thickness of 7 to 10 mm Patients with More Than Three Unsuccessful Transplants (RIF) Poor Responder Patients with Endometriosis Patients with Adenomyosis Patients whose Embryos are the Result of TESE or Severe male PGD candidate patients

Design outcomes

Primary

MeasureTime frame
• Biochemical and clinical pregnancy rates. Timepoint: • 2 weeks after embryo transfer. Method of measurement: • By doing the B-HCG test• By transvaginl sonography.

Secondary

MeasureTime frame
Pregnancy. Timepoint: • 2 weeks after embryo transfer. Method of measurement: • By transvaginl sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmeneh Keshavarzi

Shiraz University of Medical Sciences

a.keshavarzi2877@yahoo.com+98 71 3230 5410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026