Efficacy of a combination herbal ointment on the prevention of radiation burning in breast cancer

Efficacy of a combination herbal ointment (pomegranate peel, alum, honey, and oak apple) on the prevention of radiation-induced dermatitis during adjuvant radiation in patients with breast cancer after conservative breast surgery: A randomized controlled trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220904055879N1

Enrollment

100

Registered

2022-12-10

Start date

2022-11-22

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

radiation dermatitis. Erythema ab igne [dermatitis ab igne]

Interventions

Intervention 1: Intervention group: Administration of the Compound herbal remedy including the extracts of pomegranate peel, alum, honey, and oak apple starts from the first radiotherapy session. It i

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Pathology of breast cancer Breast conserving surgery with or without lymph node dissection The average time interval between chemotherapy and radiation therapy is 3-4 weeks

Exclusion criteria

Exclusion criteria: prior radiotherapy prior chemotherapy skin involvement connective tissue disease diabetes nor chronic kidney disease rash, ulcer or skin infection in the site of radiation systemic infection Existing nonhealing scar in the site of radiation concomitant local treatment cigarette or drugs addiction Patient unwillingness to participate in the study

Design outcomes

Primary

Measure	Time frame
Dermatitis Grade. Timepoint: Weekly. Method of measurement: inspection.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShakiba Javadi

Shiraz University of Medical Sciences

shakibaa89@gmail.com+98 71 3612 5337

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026