Severe pneumonia. Sepsis due to Streptococcus pneumoniae
Conditions
Interventions
Intervention 1: Intervention group: This group will receive 100 mg propolis tablets bought from suren tek company twice a day for 7 days. The patient's condition and consumption of supplements will be
Sponsors
Oroumia University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: the patient must be at least 18 years old and should be diagnosed with pneumonia which requires medicinal intervention pneumonia symptoms including: cough which has just started or gotten worst, purulent sputum, witnessing pneumonia-related symptoms in the chest examination, dyspnea (a breathing rate more than 20 per minute) or tachycardia, or mechanical ventilation should be seen in the first 72 hours 2 or more of the SIRS symptoms in the last 24 hours including: a body temperature below 36 or above 38, heartbeat above 90 per minute, Breathing rate above 20 per minute, or a CO2 blood concentration above 4.2 KPa, WBC>12000/mm3, OR10%
Exclusion criteria
Exclusion criteria: ashtma allergies known rheumatological diseases acute heart failure malignancies cystic fibrosis and chronic kidney failure with a GFR below 30 ml/min hepatic failure with a C child score a history of allergy to propolis usage of any other antioxidants patients with a transplanted organ patients receiving immunosuppressive drugs pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measuring the ESR parameter (erythrocyte sedimentation rate). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: ESR: will be measured by observing.;CRP (C reactive protein) levels. Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: CRP: will be measured with special kits. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measuring MDA levels (malondialdehyde). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by MDA kits purchased from Padgine Teb Co.;Measuring TAC levels (Total antioxidant capacity). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by TCA kits purchased from Padgine Teb Co.;WBC changes (White blood cells). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by cell counter device.;Reducing the length of hospitalization. Timepoint: From admission to discharge. Method of measurement: Based on the date of admission and discharge recorded in the patient's file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParsa Sameei
Oroumia University of Medical Sciences
Outcome results
None listed