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Clinical trial of the effectiveness of oral clonidine on pain severity and morphine requirement in patients with orthopedic fractures

Clinical trial of the effectiveness of oral clonidine on pain severity and morphine requirement in patients with orthopedic fractures with history of opioids drug abuse in emergency ward

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220822055774N1
Enrollment
64
Registered
2022-09-20
Start date
2022-11-01
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone fracture. Fracture of bone following insertion of orthopedic implant, joint prosthesis, or bone plate

Interventions

Intervention 1: Intervention group 1: will receive 0.2 mg of oral clonidine after entering the emergency room. Intervention 2: Control group: They will receive placebo pills from the person responsibl

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years old with bone fractures, and pain score >5 based on VASS History of opioid drug abuse Consent to participate in the study

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding women History of underlying cardio-pulmonary, renal diseases high blood pressure Thrombocytopenia Asthma Use of narcotics other than morphine The patient's urgent need for blood transfusion or resuscitation

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Before the intervention and 30 minutes, 1 hour, 3 hours and 6 hours after the intervention. Method of measurement: Visual pain intensity measurement scale.

Secondary

MeasureTime frame
Hemodynamic symptoms (systolic and diastolic blood pressure, heart rate, arterial blood oxygen saturation). Timepoint: Before the intervention and 30 minutes, 1 hour, 3 hours and 6 hours after the intervention. Method of measurement: Monitoring device.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Rostamipour

Kerman University of Medical Sciences

zahra.rostami.poor.2365@gmail.com31320500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026