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The Effect of Concurrent Aerobic-ResistanceTraining Period as Well as with Tribulus supplementation on cellular enzymes, inflammatory and metabolic markers, Brain-derived neurotrophic factor, memory and sexual function of overweight postmenopausal women

The Effect of Concurrent Aerobic-ResistanceTraining Period as Well as with Tribulus supplementation on cellular enzymes, inflammatory and metabolic markers,Brain-derived neurotrophic factor, memory and sexual function of overweight postmenopausal women

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220821055765N1
Enrollment
90
Registered
2022-09-23
Start date
2022-09-15
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Menopause with excess weight. Menopausal and female climacteric states

Interventions

Intervention 1: Intervention group: First, high-intensity combined exercise for 10 weeks, 3 days a week and for 60 minutes each day, which included 5 minutes of warm-up, 20 minutes of aerobic exercise

Sponsors

Islamic Azad University Rasht Branch
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
55 Years to 65 Years

Inclusion criteria

Inclusion criteria: All participants have overweight. For all participants, one year passed from their last menstrual period (they are all menopause). Non of participants had hormone treatment. All participants reported difficulties from menopause. All participants had less than 1 hour exercise per week for the last year.

Exclusion criteria

Exclusion criteria: Participants who are smokers (they smoked for 6 months before starting the research). Participants with uncontrolled cardiovascular, renal, pulmonary, thyroid, and blood pressure diseases. Participants with limited mobility and musculoskeletal injury.

Design outcomes

Primary

MeasureTime frame
The role of brain-derived neurotrophic factor in the flexibility of the central nervous system, memory and its relationship with both strength and aerobic sports activities. Timepoint: Neurotrophic factor was measured at the beginning of the study, 70 days after the intervention and 3 months after the end of the study. Method of measurement: Measurement of neurotrophic factor with ELISA laboratory kit.;Estradiol hormone changes. Timepoint: Estradiol measurement was done at the beginning of the study, 70 days after the intervention and 3 months after the end of the study. Method of measurement: Estradiol measurement by enzyme method with ELISA laboratory kit.;Testosterone hormone changes in menopausal women. Timepoint: Testosterone was measured at the beginning of the study and 70 days after the intervention. Method of measurement: Testosterone measurement by enzyme method with ELISA laboratory kit.

Secondary

MeasureTime frame
Prospective and retrospective memory scores by Crawford et al based on a five-point Likert scale. Timepoint: Memory measurement was done at the beginning of the study, 70 days after the intervention and 3 months after the end of the study. Method of measurement: Measuring memory with Crawford et al.'s questionnaire based on a five-point Likert scale.;Cortisol assessment after menopause. Timepoint: Cortisol was measured at the beginning of the study and 70 days after the intervention (at 8 am). Method of measurement: Cortisol measurement with ELISA laboratory kit.;Anthropometric index in postmenopausal women. Timepoint: Anthropometric measurement was done at the beginning of the study, 70 days after the intervention and 3 months after the end of the study. Method of measurement: Anthropometric measurement by caliper with Jackson-Pollack three point method and using body density formula and Satiety equation.;Changes in sexual self-efficacy in menopause. Timepoint: Sexual self-efficacy was measured at the beginning of the study, 70 days after the intervention and 3 months after the end of the study. Method of measurement: Measuring sexual efficiency with the Schwartz sexual questionnaire.;Plasma inflammatory index in postmenopausal women. Timepoint: The inflammatory index was measured at the beginning of the study and 70 days after the intervention. Method of measurement: Measurement of plasma inflammatory index by immunoturbidometric method.;Selected indicators of cell damage in postmenopausal women. Timepoint: Variables were measured at the beginning of the study and 70 days after the intervention. Method of measurement: Measurement of the selected index of cell damage with the German standardized enzymatic method and autoanalyzer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoya Seighali

Islamic Azad University Rasht Branch

roya.seighaly@gmail.com+98 13 3376 2536

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026