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The effect of dexmedetomidine in reducing pain after jaw surgery

Comparison of opioid requirement and pain intensity after mandibular surgeries in intraoperative infusion and bolus injection during dexmedetomidine extubation: a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220819055746N1
Enrollment
40
Registered
2022-08-29
Start date
2022-08-20
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fracture of mandible. Fracture of mandible

Interventions

Intervention 1: Intervention group: After surgery and before extubation, 5.0 mg/kg of dexmedetomidine will be infused. VAS will be measured. Also, the number of times needed for opioid medication will

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age above 18 years Candidate for mandibular surgery Consent to participate in the study

Exclusion criteria

Exclusion criteria: History of allergy to dexmedetomidine Multi-trauma patients Addiction to drugs and psychoactive substances History of taking antidepressants History of previous mandible, maxilla and cheek surgery during the last three months Patients diagnosed with rheumatoid arthritis Patients with kidney and liver diseases Dialysis patients Patients receiving anticoagulant drugs Patients with a history of systemic infections Patients with hemostatic disorders

Design outcomes

Primary

MeasureTime frame
Pain intensity. Timepoint: during recovery, the first, second, fourth, sixth, twelfth and twenty-fourth hours after discharge from recovery. Method of measurement: Visual Analogue Scale.;The amount of using opioid. Timepoint: during recovery, the first, second, fourth, sixth, twelfth and twenty-fourth hours after discharge from recovery. Method of measurement: The amount of pain during recovery is measured in the first, second, fourth, sixth, twelfth and twenty-fourth hours after discharge from recovery. If the Visual Analogue Scale is higher than 5, pethidine (Exir-Iran company) at the rate of 1 mg/kg will be injected intramuscularly. After four hours, in case of recurrence of pain, the pethidine injection will be repeated at the rate of 1mg/kg. The number of times the patient needs pethidine in twenty-four hours will be recorded.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeed Nezafati

Tabriz University of Medical Sciences

nezaf2000@yahoo.com+98 44 3344 4598

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026