polycystic ovarian syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Intervention group: taking a daily dosage of 800mg resveratrol pills ( in 2 capsules of 400mg, one in the morning and one at noon) from mega resveratrol company for 60 days leading to
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: patients must be infertile due to PCOS and aged between 18 and 40. PCOS is diagnosed based on Rotterdam criteria and having 2 of 3 criteria is enough for diagnosis: amenorrhea or oligomenorrhea, clinical or biochemical hyperandrogenism manifestations, observation of cysts in ovary sonography (at least 12 follicles with diameter of 2 - 9 mm or an increase in ovary volume more than 10cm in tans-vaginal ultrasound radiography).
Exclusion criteria
Exclusion criteria: pregnancy adrenal hyperplasia androgen secreting tumors hyperprolactinemia thyroid malfunction diabetes/glucose intolerance male infertility factors BMI > 30 taking anti-oxidant supplements less than 6 months prior to entering the study. taking ovulation stimulating drugs less than 6 months prior to entering the study. taking drugs with effect on hormone profile less than 6 months prior to entering the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Caspase 3 gene expression. Timepoint: after 60 days of intervention. Method of measurement: real time PCR.;Caspase 7 gene expression. Timepoint: after 60 days of intervention. Method of measurement: real time PCR.;Survivin gene expression. Timepoint: after 60 days of intervention. Method of measurement: real time PCR.;Serum testosterone. Timepoint: before/after intervention (60 days). Method of measurement: elisa.;Serum insulin. Timepoint: before/after intervention (60 days). Method of measurement: elisa.;Serum glucose. Timepoint: before/after intervention (60 days). Method of measurement: Enzyme kit.;Serum sex hormone binding globulin. Timepoint: before/after intervention (60 days). Method of measurement: elisa.;High-density lipoprotein cholesterol. Timepoint: before/after intervention (60 days). Method of measurement: Enzyme kit.;Serum low-density lipoprotein. Timepoint: before/after intervention (60 days). Method of measurement: Enzyme kit.;Total cholesterol. Timepoint: before/after intervention (60 days). Method of measurement: Enzyme kit.;Triglyceride. Timepoint: before/after intervention (60 days). Method of measurement: Enzyme kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Count and quality of oocyte. Timepoint: after 60 days of intervention. Method of measurement: counting, optical microscope.;Count and quality of embryo. Timepoint: 48-72 hours after ICSI. Method of measurement: counting, optical microscope.;Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: serum beta HCG test.;Clinical pregnancy. Timepoint: 4 weeks after embryo transfer. Method of measurement: ultra-sound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Shabani Nashtaei
Tehran University of Medical Sciences
Outcome results
None listed