The Effect of Intracoronary Adenosine Injection on Outcomes of Primary Percutaneous Intervention in Patients with ST-segment Elevation Myocardial Infarction

The Effect of Intracoronary Adenosine Injection on Outcomes of Primary Percutaneous Intervention in Patients with ST-segment Elevation Myocardial Infarction; A randomized controlled clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220809055645N6

Enrollment

120

Registered

2023-06-07

Start date

2023-06-20

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute transmural myocardial infarction of unspecified site. ST elevation (STEMI) myocardial infarction of unspecified site

Interventions

Intervention 1: Intervention group: Adenosine injection. Intervention 2: Control group: No adenosine injection/routine care with 5 cc of normal saline.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Diagnosis of STEMI in the emergency department Having complete criteria for primary PCI TIMI flow grade= 0-0-1 Coronary angiography Informed consent

Exclusion criteria

Exclusion criteria: Cardiogenic shock Complete AV block Severe renal failure (serum creatinine> 3 mg/dL) Need for emergency coronary artery bypass surgery History of recurrent coronary artery disease

Design outcomes

Primary

Measure	Time frame
(Major adverse cardiac events) MACE, which in this study is a combination of cardiac death, non-fatal myocardial infarction, any re-angiogenesis and stroke, and are defined according to The Academic Research Consortium. Timepoint: Within forty days after the intervention. Method of measurement: All patients will be followed up for MACE for 40 days, either through clinic visits or telephone interviews.	—

Measure

Time frame

(Major adverse cardiac events) MACE, which in this study is a combination of cardiac death, non-fatal myocardial infarction, any re-angiogenesis and stroke, and are defined according to The Academic Research Consortium. Timepoint: Within forty days after the intervention. Method of measurement: All patients will be followed up for MACE for 40 days, either through clinic visits or telephone interviews.

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Secondary

Measure	Time frame
No-reflow phenomenon refers to the lack of blood flow after coronary artery reopening. Timepoint: before and immediately after primary angioplasty. Method of measurement: based on angiographic criteria such as TIMI flow grade and TIMI frame count.;ST-segment resolution (STR) is considered if the ST segment returns more than 70% to the isoelectric line 90 minutes after injection. Timepoint: before and 90 minutes after intervention. Method of measurement: Standard 12-lead ECG will be taken from all patients at hospital admission and 90 minutes after PPCI. The sum of ST segment elevation, 20ms after the J point in all leads will be recorded. After calculating the total increase in ST-segment elevation in leads representing the infarct location on the baseline ECG and at minute 90, STR will be expressed as a percentage by dividing the second number by the first number and subtracting it from 100.;Left ventricular ejection fraction (LVEF) refers to how well the left ventricle pumps blood with each contraction. Timepoint: Before the intervention and 40 days after the intervention. Method of measurement: By a cardiologist with an echocardiography device using the Biplaine Simpson method, then the percentage of LVEF recovery will be calculated as the difference between the initial LVEF and 40 days later.	—

Measure

Time frame

No-reflow phenomenon refers to the lack of blood flow after coronary artery reopening. Timepoint: before and immediately after primary angioplasty. Method of measurement: based on angiographic criteria such as TIMI flow grade and TIMI frame count.;ST-segment resolution (STR) is considered if the ST segment returns more than 70% to the isoelectric line 90 minutes after injection. Timepoint: before and 90 minutes after intervention. Method of measurement: Standard 12-lead ECG will be taken from all patients at hospital admission and 90 minutes after PPCI. The sum of ST segment elevation, 20ms after the J point in all leads will be recorded. After calculating the total increase in ST-segment elevation in leads representing the infarct location on the baseline ECG and at minute 90, STR will be expressed as a percentage by dividing the second number by the first number and subtracting it from 100.;Left ventricular ejection fraction (LVEF) refers to how well the left ventricle pumps blood with each contraction. Timepoint: Before the intervention and 40 days after the intervention. Method of measurement: By a cardiologist with an echocardiography device using the Biplaine Simpson method, then the percentage of LVEF recovery will be calculated as the difference between the initial LVEF and 40 days later.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Baharvand

Rasht University of Medical Sciences

dr.baharcardio@gmail.com+98 13 3366 4282

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026