Effect of intravenous midazolam on radial artery spasm during performing coronary angiography

Investigation the effect of intravenous midazolam on radial artery spasm during performing coronary angiography – Randomized double blinded placebo control clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220809055645N2

Enrollment

Registered

2023-04-03

Start date

2023-03-21

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Radial Artery Spasm. Diseases of arteries, arterioles and capillaries

Interventions

Intervention 1: Intervention group: Immediately before the start of the procedure, they are injected with half a milligram of intravenous Midazolam (28) from Caspian Pharmaceutical Company. Interventi

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who undergo elective coronary angiography through right radial artery access.

Exclusion criteria

Exclusion criteria: Patient dissatisfaction Use of arterial access other than right radial artery (including femoral, brachial and left radial artery) Emergency patients Hemodynamic disorder Cardiogenic shock History of allergy to benzodiazepine History of severe respiratory complications Pregnancy and lactation History of AV fistula in the same hand Patients who are not candidates for radial angiography

Design outcomes

Primary

Measure	Time frame
Radial artery spasm. Timepoint: During and immediately after the completion of angiography. Method of measurement: The three components of the visual analogue scale are the measure of sympathetic stimulation (including SBP increase and HR increase during the procedure) and radial artery spasm.	—

Secondary

Measure	Time frame
Duration of the procedure. Timepoint: Immediately after the completion of angiography. Method of measurement: The time interval from the start of vein finding to the exit of the angiography sheet.;Duration of fluoroscopy. Timepoint: Immediately after the completion of angiography. Method of measurement: It is reported by the Siemens angiography device in the exam protocol section.;Patient willingness to use radial access in the next possible angiography procedure. Timepoint: Immediately after the completion of angiography. Method of measurement: Ask the patient.	—

Measure

Time frame

Duration of the procedure. Timepoint: Immediately after the completion of angiography. Method of measurement: The time interval from the start of vein finding to the exit of the angiography sheet.;Duration of fluoroscopy. Timepoint: Immediately after the completion of angiography. Method of measurement: It is reported by the Siemens angiography device in the exam protocol section.;Patient willingness to use radial access in the next possible angiography procedure. Timepoint: Immediately after the completion of angiography. Method of measurement: Ask the patient.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Baharvand

Rasht University of Medical Sciences

dr.baharcardio@gmail.com+98 13 3366 4282

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026