Effect of combined exercise training on subclinical hypothyroidism variables

Effect of a 12-week combined exercise training program on lipid peroxidation, total antioxidant capacity, high-sensitivity C-reactive protein, body composition, physical function, and lipid profile in women with subclinical hypothyroidism

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220809055643N1

Enrollment

Registered

2022-08-16

Start date

2022-09-06

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothyroidism.

Interventions

Intervention 1: Intervention group: receiving a resistance exercise program with an elastic band and performing an aerobic program on a treadmill or an exercise bike. Intervention 2: Intervention gro

Eligibility

Sex/Gender

Female

Age

35 Years to 49 Years

Inclusion criteria

Inclusion criteria: TSH between 5 and 10 mu/l No special disease and no medication Same body mass index No pregnant no regular exercise training for at least six months before participating in this study No smoking No alcohol consumption Not using food supplements containing zinc, magnesium and vitamin A during the last 3 months

Exclusion criteria

Exclusion criteria: Diagnosis of the attending physician regarding the need to withdraw from the study Personal desire to withdraw from the study Getting other diseases

Design outcomes

Primary

Measure	Time frame
Lipid peroxidation. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measurement of malondialdehyde through blood sample taken by valid laboratory kits.;Total antioxidant capacity. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measurement of antioxidant capacity through blood samples taken by valid laboratory kits.;C-reactive protein with high sensitivity. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measurement of C-reactive protein level in blood sample by valid laboratory kits.;Blood lipid profile. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measuring the level of lipid profile in the blood sample by valid laboratory kits.;Body fat percentage. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measurement of the thickness of subcutaneous fat (triceps brachialis, Supraspinatus and thigh) using calipers and formula calculations.;Waist to hip ratio. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measure waist circumference at the narrowest point divided by hip circumference at the widest point.;Body mass index. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measure weight in kilograms by height in meters to the power of two.	—

Measure

Time frame

Lipid peroxidation. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measurement of malondialdehyde through blood sample taken by valid laboratory kits.;Total antioxidant capacity. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measurement of antioxidant capacity through blood samples taken by valid laboratory kits.;C-reactive protein with high sensitivity. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measurement of C-reactive protein level in blood sample by valid laboratory kits.;Blood lipid profile. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measuring the level of lipid profile in the blood sample by valid laboratory kits.;Body fat percentage. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measurement of the thickness of subcutaneous fat (triceps brachialis, Supraspinatus and thigh) using calipers and formula calculations.;Waist to hip ratio. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measure waist circumference at the narrowest point divided by hip circumference at the widest point.;Body mass index. Timepoint: 24 hours before the beginning of the interventions - 48 hours after the end of the interventions. Method of measurement: Measure weight in kilograms by height in meters to the power of two.

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Secondary

Measure	Time frame
Lipid peroxidation. Timepoint: 48 hours after the last training session. Method of measurement: Malondialdehyde measurement through a blood sample taken by a valid laboratory kit.;Total antioxidant capacity. Timepoint: 48 hours after the last training session. Method of measurement: Measuring the antioxidant capacity of blood by valid laboratory kits.;C-reactive protein with high sensitivity. Timepoint: 48 hours after the last training session. Method of measurement: Measurement of C-reactive protein level in blood by valid laboratory kits.;Lipid profile. Timepoint: 48 hours after the last training session. Method of measurement: Measurement of lipid profile components in blood by valid laboratory kits.;Body fat percentage. Timepoint: 48 hours after the last training session. Method of measurement: Measurement of the thickness of subcutaneous fat (triceps brachialis, Supraspinatus and thigh) using calipers and formula calculations.;Waist to hip ratio. Timepoint: 48 hours after the last training session. Method of measurement: Waist circumference at the lowest point divided by hip circumference at the widest part.;Body mass index. Timepoint: 48 hours after the last training session. Method of measurement: Weight in kilograms divided by height in meters to the power of two.	—

Measure

Time frame

Lipid peroxidation. Timepoint: 48 hours after the last training session. Method of measurement: Malondialdehyde measurement through a blood sample taken by a valid laboratory kit.;Total antioxidant capacity. Timepoint: 48 hours after the last training session. Method of measurement: Measuring the antioxidant capacity of blood by valid laboratory kits.;C-reactive protein with high sensitivity. Timepoint: 48 hours after the last training session. Method of measurement: Measurement of C-reactive protein level in blood by valid laboratory kits.;Lipid profile. Timepoint: 48 hours after the last training session. Method of measurement: Measurement of lipid profile components in blood by valid laboratory kits.;Body fat percentage. Timepoint: 48 hours after the last training session. Method of measurement: Measurement of the thickness of subcutaneous fat (triceps brachialis, Supraspinatus and thigh) using calipers and formula calculations.;Waist to hip ratio. Timepoint: 48 hours after the last training session. Method of measurement: Waist circumference at the lowest point divided by hip circumference at the widest part.;Body mass index. Timepoint: 48 hours after the last training session. Method of measurement: Weight in kilograms divided by height in meters to the power of two.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Najafi

Shahrekord University

azamianakbar@yahoo.com0098-038- 32324401-07

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026