Comparing the effectiveness of stem cell conditioned medium and platelet-rich plasma injection in combination with noncross-linked hyaluronic acid in the treatment of atrophic acne scars.

A comparative study of the efficacy of Wharton jelly mesenchymal stem cell conditioned medium injection combined with hyaluronic acid and platelet rich plasma injection combined with hyaluronic acid in the treatment of atrophic acne scars in patients treated with CO2 fractional laser: a double-blind clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220808055641N3

Enrollment

Registered

2023-01-07

Start date

2023-01-20

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acne atrophic scar. Atrophic disorders of skin

Interventions

Intervention 1: Intervention group: In group A, all patients in one half of the face received 2 cc mesenchymal stem cell conditioned medium from Wharton jelly in combination with 2 cc injection of non

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Existence of atrophic acne scar treated with CO2 fractional laser

Exclusion criteria

Exclusion criteria: Age less than 18 years or more than 65 years Atrophic scar created in the last 6 months Conducting therapeutic intervention for atrophic scar in the last one month except CO2 fractional laser Bleeding and coagulation disorder pregnancy breastfeeding

Design outcomes

Primary

Measure	Time frame
Improvement of acne atrophic scar. Timepoint: The beginning of the study and 1 month after the start of the study and 3 months after the start of the study. Method of measurement: sonography;visioface;biometery;cutometery,physician global assessment score;patient global assessment score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Jafarzadeh

Iran University of Medical Sciences

Alirezajafarzadeh8@gmail.com+98 919 890 7445

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026