Comparing the efficacy of platelet-rich plasma and non-cross-linked hyaluronic acid injection and their combination in the treatment of atrophic acne scars

Comparison of the effectiveness of platelet-rich plasma injection with noncross-linked hyaluronic acid injection and platelet-rich plasma injection in combination with noncross linked hyaluronic acid in patients treated with fractional CO2 laser in the treatment of atrophic acne scars ; A double-blind clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220808055641N2

Enrollment

Registered

2022-09-26

Start date

2022-09-21

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acne atrophic scar. Atrophic disorders of skin

Interventions

Intervention 1: Intervention group: Injection of platelet-rich plasma in a volume of 2 cc, which is obtained after collecting whole blood from the study subjects, in the amount of 10 cc and centrifugi

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Existence of atrophic acne scar treated with CO2 fractional laser

Exclusion criteria

Exclusion criteria: Age less than 18 years or more than 50 years Atrophic scar created in the last 6 months Conducting therapeutic intervention for atrophic scar in the last one month except CO2 fractional laser Bleeding and coagulation disorder pregnancy breastfeeding

Design outcomes

Primary

Measure	Time frame
Improvement of acne atrophic scar. Timepoint: The beginning of the study and 1 month after the start of the study and 3 months after the start of the study. Method of measurement: sonography;visioface;biometery;cutometery,physician global assessment score;patient global assessment score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Jafarzadeh

Iran University of Medical Sciences

Alirezajafarzadeh8@gmail.com+98 919 890 7445

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026