Comparison of Transcranial Direct Current Stimulation (tDCS) Alone and Combined with Cognitive Rehabilitation on Improving Attention, Memory, and Inhibitory Control in Patients with Multiple Sclerosis

The Effect of Trans-cranial Direct Current Stimulation and Cognitive Rehabilitation on Cognitive Functions and Neuronal plasticity in Patients with Multiple Sclerosis: A Randomized Controlled Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220803055606N3

Enrollment

Registered

2025-09-20

Start date

2025-09-23

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple sclerosis

Interventions

Intervention 1: First intervention group: Patients will undergo ten sessions of transcranial direct current stimulation (tDCS). Each session lasts 30 minutes over two weeks (five sessions per week). T

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Diagnosis of relapsing remitting multiple sclerosis (RRMS) by a neurologist Age between 18 and 50 years Mild disability with EDSS less than 5 Presence of cognitive impairment based on neurocognitive tests (more than 2 SD below the mean in attention or inhibitory control) Willingness and informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Presence of psychiatric disorder requiring antipsychotic treatment History of seizure or epilepsy Left handed individuals Recent MS relapse in the past month requiring steroid therapy Pregnancy History of brain surgery or intracranial metallic clip Unwillingness or inability to complete intervention sessions

Design outcomes

Primary

Measure	Time frame
Change in attention score on the Integrated Visual and Auditory Continuous Performance Test in patients with multiple sclerosis. Timepoint: At baseline before starting the intervention; and immediately after completion of ten intervention sessions over two weeks. Method of measurement: Administration of the Integrated Visual and Auditory Continuous Performance Test using the standard computerized procedure, recording attention scores according to the official test manual.	—

Measure

Time frame

Change in attention score on the Integrated Visual and Auditory Continuous Performance Test in patients with multiple sclerosis. Timepoint: At baseline before starting the intervention; and immediately after completion of ten intervention sessions over two weeks. Method of measurement: Administration of the Integrated Visual and Auditory Continuous Performance Test using the standard computerized procedure, recording attention scores according to the official test manual.

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Secondary

Measure	Time frame
Change in serum level of brain derived neurotrophic factor in patients with multiple sclerosis. Timepoint: At baseline before starting the intervention; and immediately after completion of ten intervention sessions over two weeks. Method of measurement: Measurement of serum brain derived neurotrophic factor level using enzyme linked immunosorbent assay according to the manufacturer’s instructions.	—

Measure

Time frame

Change in serum level of brain derived neurotrophic factor in patients with multiple sclerosis. Timepoint: At baseline before starting the intervention; and immediately after completion of ten intervention sessions over two weeks. Method of measurement: Measurement of serum brain derived neurotrophic factor level using enzyme linked immunosorbent assay according to the manufacturer’s instructions.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mehrdad Roozbeh

Shahid Beheshti University of Medical Sciences

mehrdadroozbeh@gmail.com+98 21 5541 9005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026