Cornelian cherry fruit extract in patients with non-alcoholic fatty liver disease.

Effect of cornelian cherry fruit extract on the inflammatory (IL-6) and oxidative (GPx) factors in patients with non-alcoholic fatty liver disease.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220726055558N1

Enrollment

Registered

2022-10-19

Start date

2022-11-29

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: People with non-alcoholic fatty liver with grades 1, 2, 3. Condition 2: People with non-alcoholic fatty liver with grades 1, 2, 3. Nonalcoholic steatohepatitis (NASH) Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group:Intervention group: 20 cc (twice a day in the morning and at night for 12 weeks) of blueberry fruit extract (cornus mas L.) standardized on the basis of total anthoc

Eligibility

Sex/Gender

All

Age

25 Years to 65 Years

Inclusion criteria

Inclusion criteria: ALT levels more than U/L 30 in men a age 25-65 years diagnosis of NAFLD and patients with grade 1, 2 and 3 fatty liver willingness and consent of the person to participate in the study Being a native of Yazd ALT levels greater than U/L 19 in women

Exclusion criteria

Exclusion criteria: History of diseases including liver cirrhosis, viral hepatitis, cardiovascular diseases History of taking drugs, including corticosteroids, or any drug affecting blood sugar any drug or supplement affecting the liver within 1 month before the study history of following a specific diet within 1 month before the study breastfeeding and pregnancy alcohol consumption

Design outcomes

Primary

Measure	Time frame
Interleukin 6. Timepoint: Before the intervention and the end of the intervention after 12 weeks. Method of measurement: Measurement of plasma glutathione peroxidase by ELISA method.;Glutathione peroxidase. Timepoint: Before the intervention and the end of the intervention after 12 weeks. Method of measurement: Measurement of plasma glutathione peroxidase by ELISA method.	—

Secondary

Measure	Time frame
Waist circumference. Timepoint: Before the intervention and the end of the intervention after 12 weeks. Method of measurement: Inflexible meter.;Hip circumference. Timepoint: Before the intervention and the end of the intervention after 12 weeks. Method of measurement: Inflexible meter.;Weight. Timepoint: Before the intervention and the end of the intervention after 12 weeks. Method of measurement: SECA scales.	—

Measure

Time frame

Waist circumference. Timepoint: Before the intervention and the end of the intervention after 12 weeks. Method of measurement: Inflexible meter.;Hip circumference. Timepoint: Before the intervention and the end of the intervention after 12 weeks. Method of measurement: Inflexible meter.;Weight. Timepoint: Before the intervention and the end of the intervention after 12 weeks. Method of measurement: SECA scales.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMr. Dr. Hassan Mozafari Khosravi

Yazd University of Medical Sciences

ravabet.odb@ssu.ac.ir009838209100

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026