The effect of respiratory muscle training and N-acetyl cysteine supplementation on hematological profile, blood gases, some inflammatory markers, mood, sleep quality and lung scan

The effect of respiratory muscle training and N-acetyl cysteine supplementation on hematological profiles, blood gases, some inflammatory markers, mood, sleep quality, and sleep quality in hospitalized pulmonary patients with corona virus infection.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220724055541N1

Enrollment

104

Registered

2022-08-30

Start date

2022-09-02

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corona virus. COVID-19, virus identified

Interventions

Intervention 1: The first intervention group: 1000 mg of N-acetylcysteine by injection twice a day every 12 hours for two weeks as an IV and in the continuation of the intervention two weeks after dis

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Willingness to cooperate with the plan 18 to 65 years old Patients with COVID-19 whose disease has been fully confirmed through complete medical examination, pathology and laboratory information Patients with COVID-19 in non-critical conditions and not hospitalized in the intensive care unit

Exclusion criteria

Exclusion criteria: smoking alcohol consumption Pregnancy and breastfeeding People who, in addition to COVID-19, have other diseases, such as severe kidney, liver, thyroid and parathyroid, glandular, gastrointestinal diseases, and heart and cancer patients.

Design outcomes

Primary

Measure	Time frame
The percentage of changes in lung involvement. Timepoint: Before the intervention and 4 weeks after the intervention. Method of measurement: Lung scan.;State of mind. Timepoint: Before the intervention, 4 weeks after the intervention and 2 months after the intervention. Method of measurement: DASS 21 question questionnaire.	—

Secondary

Measure	Time frame
Hematological profile. Timepoint: Before the intervention and 4 weeks after the intervention. Method of measurement: Biochemical analyses.;Blood gasesHematological profile. Timepoint: Before the intervention and 4 weeks after the intervention. Method of measurement: Biochemical analyses.;Inflammatory markers. Timepoint: Before the intervention and 4 weeks after the intervention. Method of measurement: Biochemical analyses.;Sleep quality. Timepoint: Before the intervention, 4 weeks after the intervention and 2 months after the intervention. Method of measurement: Pittsburgh Sleep Quality Questionnaire (PSQI).	—

Measure

Time frame

Hematological profile. Timepoint: Before the intervention and 4 weeks after the intervention. Method of measurement: Biochemical analyses.;Blood gasesHematological profile. Timepoint: Before the intervention and 4 weeks after the intervention. Method of measurement: Biochemical analyses.;Inflammatory markers. Timepoint: Before the intervention and 4 weeks after the intervention. Method of measurement: Biochemical analyses.;Sleep quality. Timepoint: Before the intervention, 4 weeks after the intervention and 2 months after the intervention. Method of measurement: Pittsburgh Sleep Quality Questionnaire (PSQI).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMobina Aghajani

Mazandaran University

m.aghajani01@umail.umz.ac.ir+98 21 8214 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026