Coronary Artery Bypass Graft Surgery. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: Intervention group: adding 3 gram of injectable Vitamin C ( 6 VITAMIN C DP 500MG/5ML AMP) to Del Nido cardioplegia solution (1 L Plasma-Lyte A base solution to which the following are
Sponsors
Rajaee Heart Center
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Tendency to participate Consent Age between 30 to 70 LVEF more than 30%
Exclusion criteria
Exclusion criteria: Above normal range cardiac enzymes History of sternotomy and previous cardiac surgeries History of Liver, Kidney, Pulmonary diseases Valve problems that requires concurrent surgery Having pacemaker Pregnancy History of allergic reaction to Vitamin C G6PD deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Troponin I is a cardiac and skeletal muscle protein family. It is a part of the troponin protein complex, where it binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Troponin I prevents myosin from binding to actin in relaxed muscle. When calcium binds to the troponin C, it causes conformational changes which lead to dislocation of troponin I. Afterwards, tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character. It is a useful marker in the laboratory diagnosis of heart attack. It occurs in different plasma concentration but the same circumstances as troponin T - either test can be performed for confirmation of cardiac muscle damage and laboratories usually offer one test or the other. Timepoint: pre-operation, upon admission to the Intensive Care Unit, and 24 hours later. Method of measurement: Using accurate laboratory kits.;Creatine kinase-MB (CK-MB) is a form of an enzyme found primarily in heart muscle cells. This test measures CK-MB in the blood.CK-MB is one of three forms (isoenzymes) of the enzyme creatine kinase (CK). These isoenzymes include :CK-MM (found in skeletal muscles and the heart)CK-MB (found mostly in the heart, but small amounts found in skeletal muscles)CK-BB (found mostly in the brain and smooth muscle, such as the intestines and uterus)CK is released from muscle cells and is detectable in the blood whenever there is muscle damage. The small amount of CK that is normally in the blood is primarily CK-MM. CK-BB almost never gets into the blood, and CK-MB will typically only be present in significant amounts when the heart is damaged. A CK test measures the total level but does not distinguish between the three isoenzymes. When there is an increased amount of CK present in the blood, the CK-MB test can be used to determine whether it is due to heart damage or is more likely to be related to skeletal muscle injury. Timepoint: pre | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood urea nitrogen (BUN) is a medical test that measures the amount of urea nitrogen found in blood. The liver produces urea in the urea cycle as a waste product of the digestion of protein. Normal human adult blood should contain 6 to 20 mg/dL (2.1 to 7.1 mmol/L) of urea nitrogen. Individual laboratories will have different reference ranges as the assay used can vary between laboratories. The test is used to detect renal problems. Timepoint: pre-operation, upon admission to the Intensive Care Unit, 24 and 48 hours later. Method of measurement: Using accurate laboratory kits.;Serum creatinine (a blood measurement) is an important indicator of kidney health because it is an easily measured byproduct of muscle metabolism that is excreted unchanged by the kidneys. Creatinine itself is produced via a biological system involving creatine, phosphocreatine (also known as creatine phosphate), and adenosine triphosphate (ATP, the body's immediate energy supply). Timepoint: pre-operation, upon admission to the Intensive Care Unit, 24 and 48 hours later. Method of measurement: Using accurate laboratory kits.;Liver function tests (LFTs or LFs), also referred to as a hepatic panel, are groups of blood tests that provide information about the state of a patient's liver. The liver transaminases aspartate transaminase (AST or SGOT) and alanine transaminase (ALT or SGPT) are useful biomarkers of liver injury in a patient with some degree of intact liver function. Timepoint: pre-operation, upon admission to the Intensive Care Unit, 24 and 48 hours later. Method of measurement: Using accurate laboratory kits. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammadhadi Mozayan
Rajaee Heart Center
Outcome results
None listed