Probiotic supplementation in multiple sclerosis

Investigating the effect of probiotic supplementation compared to placebo on serum oxidative stress factors in patients with multiple sclerosis (MS)

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220713055465N2

Enrollment

Registered

2023-05-09

Start date

2022-08-23

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple Sclerosis

Interventions

Intervention 1: Intervention group: LactoCare probiotic supplement that contains high amounts of 12 beneficial and safe bacterial strains along with fructooligosaccharides as prebiotics. Patients will

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Definitive diagnosis of multiple sclerosis based on 2017 MacDonald criteria Relapsing Remitting MS (RRMS) Informed consent to participate in the study

Exclusion criteria

Exclusion criteria: The presence of other neurological diseases at the same time as MS Diabetes mellitus (DM) Anemia Other inflammatory diseases Rheumatological diseases Acute and chronic infectious diseases (including urinary tract infection) Discopathy Relapsing of the disease in the last 4 months Receiving pulse coronet during the last 4 months Progressive MS CIS (Clinically isolated syndrome) Literacy level below 12 years and lack of proficiency in Persian language Severe depression and use of antidepressants Alcohol or drug abuse Thyroid disorders Taking drugs that affect fatigue Pregnancy

Design outcomes

Primary

Measure	Time frame
Oxidative stress markers including MDA? SOD? ATC? GSH? GPX1 ? GPX2. Timepoint: Baseline and end of treatment period. Method of measurement: Based on serum samples of the patients.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnaz Talebi

Tabriz University of Medical Sciences

Talebi511@yahoo.com+98 41 3334 0730

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026