The effectiveness of the amount of intraoperative fluid administration on pulmonary complications after lobectomy of left lung

A clinical trial to compare the effectiveness of administration of the one third of intraoperative fluid with standard amount of fluid on pulmonary complications after lobectomy of left lung

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220627055294N1

Enrollment

140

Registered

2022-06-30

Start date

2022-08-23

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary complications after lobectomy. Chronic pulmonary insufficiency following surgery

Interventions

Intervention 1: Intervention group: The intervention group will receive midazolam, fentanyl and propofol to induce anesthesia, then will receive one third of fluid maintenance during surgery. Interven

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with ASA I, II or III, who are candidate for lobectomy of left lung Not having cardiovascular disease Not having kidney failure Not having systemic disease such as diabetes, hypertension and thyroid disease

Exclusion criteria

Exclusion criteria: Receiving high intraoperative blood transfusion volume greater than 50 percent of the total blood volume of patient during three hours Receiving diuretics and osmotic substances before surgery Patient cardiopulmonary arrest

Design outcomes

Primary

Measure	Time frame
The total fluid rate injection during intraoperative. Timepoint: During surgery. Method of measurement: Total volume of injected fluids in cc per kg.;Duration of anesthesia. Timepoint: After intervention. Method of measurement: The number of hours of postoperative anesthesia.;The duration of hospitalization. Timepoint: Two weeks after intervention. Method of measurement: The number days of hospitalization.;Pulmonary complications (acute respiratory distress syndrome, intubation, atelectasis, pneumonia, persistent air leaks). Timepoint: 48 hours after intervention. Method of measurement: Based on clinical examinations.;Mortality rate. Timepoint: 48 hours after intervention. Method of measurement: Calculating a mortality rate.	—

Measure

Time frame

The total fluid rate injection during intraoperative. Timepoint: During surgery. Method of measurement: Total volume of injected fluids in cc per kg.;Duration of anesthesia. Timepoint: After intervention. Method of measurement: The number of hours of postoperative anesthesia.;The duration of hospitalization. Timepoint: Two weeks after intervention. Method of measurement: The number days of hospitalization.;Pulmonary complications (acute respiratory distress syndrome, intubation, atelectasis, pneumonia, persistent air leaks). Timepoint: 48 hours after intervention. Method of measurement: Based on clinical examinations.;Mortality rate. Timepoint: 48 hours after intervention. Method of measurement: Calculating a mortality rate.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMandana Jahanian

Mashhad University of Medical Sciences

jahanianm991@mums.ac.ir+98 51 3840 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026