Type 2 diabetes mellitus. Type 2 diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group: The first intervention group: they receive one probiotic supplement capsule + 200 grams of plain yogurt per day for 12 weeks. Probiotic supplement is produced by Ta
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 69 Years
Inclusion criteria
Inclusion criteria: 50 to 69 years of age Body mass index equal to and greater than 25 to 40 Blood pressure under control (lower than 140/90 mmHg) in the last two months The score of a brief cognitive screening test (Mini-Cog) lower or equal of 2 Daily consumption of yogurt at least one serving Education level of at least five classes Hb-A1c equal to and less than 8.5 Type 2 diabetes (at least two years) Willingness to cooperate
Exclusion criteria
Exclusion criteria: Immune deficiency diseases Stage three and above of Chronic Kidney Disease (CKD) History of heart attack, congestive heart failure, stent placement Chronic Obstructive Pulmonary Disease (COPD) Stage three and above of fatty liver Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), pernicious anemia and mal-absorption such as celiac disease and chronic pancreatitis Hypothalamic tumor Uncontrolled thyroid disease Parathyroid disease Adrenal disease Gum surgery under the supervision of a dentist Gastrointestinal surgeries Less than two years recovering from cancer Less than 3 months recovering from Covid-19 Neurological diseases such as seizures, mental retardation and stroke Comorbid psychiatric disorder such as Generalized Anxiety Disorder (GAD), depression, schizophrenia, dementia, Parkinson's Diseases, and bipolar Allergy Uncontrolled hypertriglyceridemia Allergy to cow's milk protein lactose intolerance Taking any medication other than oral medications for diabetes, blood pressure, dyslipidemia, aspirin, and levothyroxine in the last two months Taking antibiotics Having a special diet Regular consumption of dietary supplements (equal to or more than 3 times a week) other than vitamin D during the two months before the study alcohol consumption smoking Being pregnant or breastfeeding Participating in other medical studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The score of the brief cognitive screening test (Mini-cog). Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (end of week 12). Method of measurement: Mini-cog, a brief cognitive screening test.;The score of Stroop color-word. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (end of week 12). Method of measurement: Stroop color-word test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Salivary cortisol. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (end of week 12). Method of measurement: Immunoassay kit.;Superoxide Dismutase (SOD). Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (end of week 12). Method of measurement: ELISA kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarsa Zaroudi
Iran University of Medical Sciences
Outcome results
None listed