Comparing the effects of levetiracetam and phenytoin in the treatment of neonatal seizures

efficacy of Levetiracetam compared to intravenous Phenytoin in treatment of acute phase of neonatal seizure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220619055221N1

Enrollment

Registered

2022-11-09

Start date

2022-11-22

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal seizure. Convulsions of newborn

Interventions

Intervention 1: Intervention group: Levetiracetam Dose 20 mg/kg starting and continuing to 10 mg/kg. Intervention 2: Intervention group: Phenytoin Dose 20 mg/kg starting and continuing to 3-5 mg/kg.

Eligibility

Sex/Gender

All

Age

1 Days to 28 Days

Inclusion criteria

Inclusion criteria: neonate with seizure term neonate up to 28 days preterm neonate up to 44 weeks of gestational age

Exclusion criteria

Exclusion criteria: neonate without seizure

Design outcomes

Primary

Measure	Time frame
Efficacy of phenytoin and levetiracetam in the treatment of neonatal seizures. Timepoint: The first 24 hours after the drug. Method of measurement: No recurrence of seizures in the first 24 hours after the drug.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParvaneh Babaey Sisi

Oroumia University of Medical Sciences

parvanehbabaey@gmail.com+98 41 4247 6768

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026