Osteoarthritis of Knee. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group 1: The first group will receive topical application of gel formulated from aqueous-methanolic (30:70) extracts of Calotropis gigantea (20%) and Curcuma longa (10%) t
Sponsors
Muhammad Nawaz Sharif University of Agriculture
Eligibility
Sex/Gender
All
Age
45 Years to 70 Years
Inclusion criteria
Inclusion criteria: According to the Kellgren and Lawrence system of grading, patients with the grade 1-2-3 knee osteoarthritis Age 45-70 years Both gender
Exclusion criteria
Exclusion criteria: Neural defects Injected with steroidal injections in the past 2 years Rheumatoid arthritis Total knee replacement
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Stiffness, Pain and Activity of daily living. Timepoint: Pre (before starting the intervention) and Post evaluation (after every 3rd session of treatment, evaluation will be done). Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC) scale. | — |
Primary
| Measure | Time frame |
|---|---|
| Inflammation. Timepoint: Pre (before starting the intervention) and Post evaluation (after 3-4 weeks when treatment sessions/ intervention will be completed depending on different individual and conditions or grades of different individuals). Method of measurement: Interleukin-6 and Tumor necrotic factor alpha.;Pain. Timepoint: Pre (before starting the intervention) and Post evaluation (daily after each treatment session, evaluation will be done). Method of measurement: Numeric pain rating scale (NPRS) and Pain Catastrophizing Scale (PCS). | — |
Countries
Pakistan
Contacts
Public ContactTehreem Saad Khan
Muhammad Institute of Medical and Allied Sciences, Multan
Outcome results
None listed