The Effect of Ondansetron and Ginger on Nausea/ Vomiting, Shivering and Headache in Cesarean Section Patients

Comparative Study of the Effect of Ondansetron and Ginger on Nausea/ Vomiting, Shivering and Headache after Spinal Anesthesia during and after Cesarean Section

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220614055172N1

Enrollment

150

Registered

2022-07-03

Start date

2022-08-06

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean section. Single liveborn infant, delivered by cesarean

Interventions

Intervention 1: First Intervention group: This group is the ginger group, which will first be prepared as Zintoma oral capsules (250 mg) produced by Gol Daroo Pharmaceutical Company. Then, 1000 mg gin

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age range of 20 to 40 years Physical status 1 or 2 in terms of ASA criteria Complete gestational age and singleton Cesarean candidate under spinal anesthesia

Exclusion criteria

Exclusion criteria: Unwilling to participate in the study History of mental disorders Body mass index greater than 35 Meniere's disease Digestive Disease Frequent Dora holes and failed spinal anesthesia Allergy to Ondansetron or Ginger

Design outcomes

Primary

Measure	Time frame
Nausea based on visual analog scale score. Timepoint: During cesarean section (20 minutes after the start of surgery), when leaving the recovery (30 minutes after surgery is completed), 1, 2 and 4 hours after the surgery is completed. Method of measurement: Visual analog scale.;Vomiting based on the vomiting frequency checklist. Timepoint: During cesarean section (20 minutes after the start of surgery), when leaving the recovery (30 minutes after surgery is completed), 1, 2 and 4 hours after the surgery is completed. Method of measurement: Vomiting frequency checklist.;Shivering based on the standard shivering scale score. Timepoint: During cesarean section (20 minutes after the start of surgery), when leaving the recovery (30 minutes after surgery is completed), 1, 2 and 4 hours after the surgery is completed. Method of measurement: Standard Shivering scale based on Crossley and Mahajan criteria.;Headache based on visual analog scale score. Timepoint: During cesarean section (20 minutes after the start of surgery), when leaving the recovery (30 minutes after surgery is completed), 1, 2 and 4 hours after the surgery is completed. Method of measurement: Visual analog scale.	—

Measure

Time frame

Nausea based on visual analog scale score. Timepoint: During cesarean section (20 minutes after the start of surgery), when leaving the recovery (30 minutes after surgery is completed), 1, 2 and 4 hours after the surgery is completed. Method of measurement: Visual analog scale.;Vomiting based on the vomiting frequency checklist. Timepoint: During cesarean section (20 minutes after the start of surgery), when leaving the recovery (30 minutes after surgery is completed), 1, 2 and 4 hours after the surgery is completed. Method of measurement: Vomiting frequency checklist.;Shivering based on the standard shivering scale score. Timepoint: During cesarean section (20 minutes after the start of surgery), when leaving the recovery (30 minutes after surgery is completed), 1, 2 and 4 hours after the surgery is completed. Method of measurement: Standard Shivering scale based on Crossley and Mahajan criteria.;Headache based on visual analog scale score. Timepoint: During cesarean section (20 minutes after the start of surgery), when leaving the recovery (30 minutes after surgery is completed), 1, 2 and 4 hours after the surgery is completed. Method of measurement: Visual analog scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Alizade

Hamedan University of Medical Sciences

arielalizade@gmail.com+98 81 3131 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026