Asthma. Asthma
Conditions
Interventions
Intervention 1: Intervention group: Capsules containing Boswellia serrata, Pimpinella anisum, Hyssopus officinalis, Eucalyptus, and Coriander seed. The plants needed for the research capsule will be p
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: One unplanned asthma-related visit to the emergency department or clinic in the past 12 months One night hospitalization in the last 12 months Disturbed sleep more than twice in the last month Asthma symptoms =8 times in the last month Use of a ß2 agonist =8 times in the past month Receiving two short courses (3-7 days) of oral corticosteroids in the past 12 months Funcional expiratory volume in the first second <80% predicted and use of inhalational corticosteroids (ICS) for at least 1 month prior to study entry Women of childbearing potential must be sexually inactive or use effective birth control measures, as determined by the researcher, during the study period and have a negative pregnancy test at the beginning of the study
Exclusion criteria
Exclusion criteria: People with acute illness (such as colds and flu) within two weeks before the screening visit Any history of systemic disease that the researcher believes would prevent the subject from participating in this study, including viral hepatitis, history of chronic obstructive pulmonary disease, emphysema or other chronic respiratory diseases, underlying kidney, liver, thyroid and diabetes and cardiovascular diseases, abnormal liver function (alanine aminotrasferase/aspartate aminotransferase (ALT/AST) and bilirubin more than 1.25 times the upper limit of normal), abnormal bone marrow function (White blood cells less than 4000/mm3, platelets less than 100,000/mm3 and hemoglobin less than 11 g/dL), abnormal kidney function (blood urea nitrogen (BUN) and creatinine more than 1.25 times the upper limit of normal), abnormal electrocardiogram, forced expiratory volume in 1 second (FEV1) <50% predicted Participation in another experimental treatment study within 30 days prior to this study History of alcohol or drug use Pregnant or lactating women Subjects treated with Omalizumab or immunotherapy for asthma Use of other herbal compounds for the treatment of asthma in the last month before entering the study History of allergy to one of the components of Boswellia serrata, Pimpinella anisum, Hyssopus officinalis, Eucalyptus, or Coriander seed
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Forced expiratory volume in 1 second. Timepoint: Days 30 and 90. Method of measurement: Spirometry.;Forced expiratory volume in 1 second to Forced vital capacity ratio. Timepoint: Days 30 and 90. Method of measurement: Spirometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms of asthma. Timepoint: Days 30 and 90. Method of measurement: Asthma Control Test questionnaire.;Assessment of quality of life. Timepoint: Days 30 and 90. Method of measurement: Asthma quality of life questionnaire.;Assessment of sleep quality. Timepoint: Days 30 and 90. Method of measurement: Pittsburgh Sleep Quality Index.;Adverse events. Timepoint: Days 30 and 90. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeid Safiri
Tabriz University of Medical Sciences
Outcome results
None listed