The effect of melatonin on postoperative pain

Evaluation of preoperative administration of the oral melatonin on postoperative pain in lumbar spinal surgeries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220613055157N1

Enrollment

Registered

2022-06-19

Start date

2022-02-20

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lumbar spine surgery.

Interventions

Intervention 1: Intervention group: 5 mg of oral melatonin one hour before surgery. Intervention 2: Control group: Control group: placebo one hour before surgery.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Satisfaction for participation in the study candidates for lumbar spinal surgeries

Exclusion criteria

Exclusion criteria: Lack of cooperation in the study Opioid abuse Use of any other sedatives Taking drugs that interfere with melatonin non-elective surgery coagulative disorders kidney or liver failure history of drug allergy to melatonin

Design outcomes

Primary

Measure	Time frame
Severity of post operative pain based on Visual Analogue Scale(VAS). Timepoint: Measurement of pain severity at 1, 2, 6, 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale(VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad reza Sedighi

Tehran University of Medical Sciences

m.sedighi96@gmail.com+98 21 3645 6191

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026