Patients in need of coronary artery bypass grafting.
Conditions
Interventions
Intervention 1: Intervention group: This group involve 30 person that intervention means reduction Protamine dose to the half the usual amount in they is done. In this group relative to the amount rec
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Omitting anti-coagulation drugs at least one week prior to surgery Patient should be a candidate for coronary artery bypass grafting Informed consent to participate in the study CPB duration less than 100 minutes
Exclusion criteria
Exclusion criteria: Allergy and the risk of anaphylaxia shock Coagulation abnormality Bleeding and hemostasis dysfunctions due to non-medical causes Patients dependent on dialysis and patients suffering from blood dyscrasia and known platelet dysfunction Pregnancy Heparin re-administration Need for emergency surgery Patients with BMIs higher than 30 Under 28 degrees hypothermia Dissent to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percent of participants with number of Activated Clotting Time near normal domain (70-120) second. Timepoint: 5 minutes after the end of protamine injection. Method of measurement: Activated Clotting Time assessment with Coagulometer device according to second.;Percent of abnormal bleeding. Timepoint: Drainage assessment of the drains and chest tubes 12 hours and 36 hours after the end of surgery. Method of measurement: Drainage assessment of the drains and chest tubes according to cubic centimeter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Amir MirMohammadSadeghi
Esfahan University of Medical Sciences
Outcome results
None listed