Effect of probiotics supplementation in the control of obesity

The effect of supplementation with Lactobacillus rhamnosus, Lactobacillus fermentum, and Lactobacillus plantarum on anthropometric indices, appetite, and serum level of Nesfatin, Omentin-1, LPS, liver function markers, metabolic parameters, oxidative stress, and inflammatory biomarkers in obese individuals: a triple blinded RCT

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220608055106N1

Enrollment

100

Registered

2022-07-03

Start date

2022-07-23

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight and obesity. Overweight and obesity

Interventions

Intervention 1: Intervention group: (group1) Probiotic supplement in powder sacs containing Lactobacillus fermentum 014 NIMBB (NCBI MT registration code 994667) isolated from the ridge (for 60 days).

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Obese people in the range of body mass index( 30=BMI = 40) Age group of 18-60 years Volunteers

Exclusion criteria

Exclusion criteria: Allergy to probiotics Having Diabetes, kidney disease, liver disease, Thyroid disorders Having a special diet to treat obesity in the last three months Taking corticosteroids and/ or antibiotics Regular Consumption of probiotics and/or nutritional supplements Gastric surgery Pregnancy. lactation Smoking and or drinking alcohol

Design outcomes

Primary

Measure	Time frame
Anthropometric indicators (height, weight, BMI, waist circumference). Timepoint: At first and end of two months intervention. Method of measurement: Weight scale, Meter.;Novel anthropometric indexes e.g., ABSI, BRI). Timepoint: Weight scale, Meter. Method of measurement: Weight scale, Meter, related formula.;Appetite. Timepoint: At first and end of two months intervention. Method of measurement: questionnaire.;Serum level of Nesfatin. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;Serum level of Omentin-1. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;Serum level of LPS. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;Liver function test (ALT, AST, ALP). Timepoint: At first and end of two months intervention. Method of measurement: Auto-analyzer based on the principle of photometry.;FBS. Timepoint: At first and end of two months intervention. Method of measurement: Auto-analyzer based on the principle of photometry.;Serum Insulin. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;Lipid profile ( TC, TG, LDL.C, HDL.C). Timepoint: At first and end of two months intervention. Method of measurement: Auto-analyzer based on the principle of photometry.;MDA. Timepoint: At first and end of two months intervention. Method of measurement: Spectrophotometer.;TAC. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;TOC. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;CRP. Timepoint: At first and end of two months intervention. Method of measurement: photometry.;IL-6. Timepoint: At first and end of two months intervention. Method of measurement: ELISA KIT.;IL-1 B. Timepoint: At first and end of two months intervention. Method of measurement: ELISA KIT.;TNF alfa. Timepoint: At first and end of two months intervention. Method of meas	—

Measure

Time frame

Anthropometric indicators (height, weight, BMI, waist circumference). Timepoint: At first and end of two months intervention. Method of measurement: Weight scale, Meter.;Novel anthropometric indexes e.g., ABSI, BRI). Timepoint: Weight scale, Meter. Method of measurement: Weight scale, Meter, related formula.;Appetite. Timepoint: At first and end of two months intervention. Method of measurement: questionnaire.;Serum level of Nesfatin. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;Serum level of Omentin-1. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;Serum level of LPS. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;Liver function test (ALT, AST, ALP). Timepoint: At first and end of two months intervention. Method of measurement: Auto-analyzer based on the principle of photometry.;FBS. Timepoint: At first and end of two months intervention. Method of measurement: Auto-analyzer based on the principle of photometry.;Serum Insulin. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;Lipid profile ( TC, TG, LDL.C, HDL.C). Timepoint: At first and end of two months intervention. Method of measurement: Auto-analyzer based on the principle of photometry.;MDA. Timepoint: At first and end of two months intervention. Method of measurement: Spectrophotometer.;TAC. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;TOC. Timepoint: At first and end of two months intervention. Method of measurement: Elisa kit.;CRP. Timepoint: At first and end of two months intervention. Method of measurement: photometry.;IL-6. Timepoint: At first and end of two months intervention. Method of measurement: ELISA KIT.;IL-1 B. Timepoint: At first and end of two months intervention. Method of measurement: ELISA KIT.;TNF alfa. Timepoint: At first and end of two months intervention. Method of meas

—

Secondary

Measure	Time frame
Blood urea nitrogen. Timepoint: At first and end of two months intervention. Method of measurement: autoanalyzer.;CREATININ. Timepoint: At first and end of two months intervention. Method of measurement: autoanalyzer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJamileh Ghalami

Karaj University of Medical Sciences

s_ghalami@yahoo.com+98 26 3664 8761

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026