obstructive sleep apnea. Obstructive sleep apnea (adult) (pediatric)
Conditions
Interventions
Intervention group: All patients are treated with a combination of atomoxetine and trazodone for one month, and then undergo polysomnography..
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
21 Years to 65 Years
Inclusion criteria
Inclusion criteria: Definite diagnosis of obstructive sleep apnea with AHI>15 in polysomnography lack of compliance treatment with CPAP or BIPAP either the patient is unwilling to have surgery or they are not candidates for surgery in the opinion of the expert
Exclusion criteria
Exclusion criteria: commodities' existence (excluding controlled blood pressure, hyperlipidemia and diabetes) Taking any medication that leads to changes in the physiology of breathing, sleep / wake and muscles Taking any medication that leads to changes in the physiology of breathing, sleeping / waking and muscles any underlying cardiac disease, such as arrhythmia Inability to sleep in supine position Hypersensitivity to lidocaine, atomoxetine or trazodone Pregnancy History of seizures, Panic disorder, Hyperventilation syndrome, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder any hepatic disease or failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea-hypopnea index. Timepoint: after on month medication consumption. Method of measurement: Polysomnography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum O2 saturation. Timepoint: once. Method of measurement: pulse oxymetry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactArezu Najafi
Tehran University of Medical Sciences
Outcome results
None listed