obstructive sleep apnea. Obstructive sleep apnea (adult) (pediatric)
Conditions
Interventions
Intervention 1: Intervention group: Patients are treated with 80 mg of atomoxetine (Mofid company) and 50 mg of trazodone (Razak company) once half an hour before the polysomnography test and then und
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Definite diagnosis of obstructive sleep apnea in medical history with AHI>15 in polysomnography lack of compliance treatment with CPAP or BIPAP either the patient is unwilling to have surgery or they are not candidates for surgery in the opinion of the expert
Exclusion criteria
Exclusion criteria: commodities' existence (excluding controlled blood pressure, hyperlipidemia and diabetes) any underlying cardiac disease, such as arrhythmia that is seen on the ECG History of seizures, Panic disorder, Hyperventilation syndrome, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder Hypersensitivity to lidocaine, atomoxetine or trazodone, substances used in placebo Taking any medication that leads to changes in the physiology of breathing, sleep / wake and muscles Taking any medication that leads to changes in the physiology of breathing, sleeping / waking and muscles Inability to sleep in supine position Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea-hypopnea index. Timepoint: medication Night. Method of measurement: Polysomnography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety. Timepoint: The morning after taking the drug. Method of measurement: asking the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamed Amirifard
Tehran University of Medical Sciences
Outcome results
None listed