Comparing the effectiveness of Loperamide and Diphenoxylate in controlling the output of protective ileostomy in rectal cancer patients in Sinai Hospital in 1402-1403

Comparing the effectiveness of loperamide and diphenoxylate in controlling the output of protective ileostomy in rectal cancer patients in Sinai Hospital in ????-????

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220530055031N4

Enrollment

120

Registered

2023-10-21

Start date

2023-11-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Output of ileostomy.

Interventions

Intervention 1: Intervention group: Intervention group: In this group, after ileostomy operation, they receive loperamide at a dose of 2 mg three times a day every 8 hours along with diphenoxylate at

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who underwent surgery due to rectal cancer and protective ileostomy were installed

Exclusion criteria

Exclusion criteria: Patients who have a history of taking drugs that affect the function and motility of the digestive system within 2 weeks before the study Age below 18 years

Design outcomes

Secondary

Measure	Time frame
Drug complication. Timepoint: Within 5 days of starting the drug. Method of measurement: Expert opinion.	—

Primary

Measure	Time frame
Ileostomy output. Timepoint: The second day to the sixth day after the operation every 24 hours. Method of measurement: The output of the ostoma is collected in plastic containers with appropriate labels provided by the department.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Amir Miratashi Yazdi

Tehran University of Medical Sciences

amiratashi@sina.tums.ac.ir+98 21 6312 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026