Repeated implantation failure.
Conditions
Interventions
An intervention group including 12 women with RIF (based on the inclusion and exclusion criteria) whose serum vitamin D levels were less than 20 ng/ml were selected and they were prescribed oral vitam
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: Regular menstruation (25-35 days) Not using vitamin D3 for 3 months before endometrial biopsy Not using hormonal contraceptive methods and IUD for 3 months before biopsy Age under forty A history of three failures in embryo implantation after IVF or ICSI following the transfer of the A quality embryos Infertility without a specific cause
Exclusion criteria
Exclusion criteria: Active autoimmune disease Hormonal disorders Thrombophilia Uterine anatomical problems such as myoma, fibroid, polyp, intrauterine adhesions or congenital disorders of the uterus. Endometriosis and polycystic ovarian syndrome Hydrosalpinx Infertility with male factors Vitamin D3 consumption in the last three months Age over forty Genetic and chromosomal disorders in each couple
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Women with recurrent implantation failure. Timepoint: Measuring blood vitamin D levels in two groups, measuring blood vitamin D levels in the clinical trial group after taking oral vitamin D And before starting the ART cycle. Method of measurement: Examining the serum level of vitamin D using a blood test, measuring the expression level of VDR, IGFB-P1, PR, PRL and HOXA10 genes in endometrial samples using Quantitative Reverse Transcription Polymerase Chain Reaction, measuring the level of IGFB-P1, PR, PRL and HOXA10 in endometrial samples using immunohistochemistry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. zahra shams mofarahe
Shahid Beheshti University of Medical Sciences
Outcome results
None listed