Lichen planopilaris. Follicular Lichen Planus
Conditions
Interventions
Intervention 1: Intervention group: Methotrexate ( 15 mg/week orally in one day) will be administered in one group ( 17 patients) and for 6 months. Intervention 2: Intervention group: Minoxidil 1 mg t
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Newly diagnosed patients who have not yet received treatment. Patients who have previously been treated and whose disease is still active according to clinical and dermoscopic criteria Patients should have discontinued any previous systemic medication 1 month before entering the study and should not use any systemic or topical medication at the time of the study
Exclusion criteria
Exclusion criteria: pregnancy or breastfeeding Leukocytes <3000 Platelets <100000 Hemoglobin <9 Liver enzymes more than 2 times the reference limit Positive for viral hepatitis tests History of cardiovascular disease and hypotension History of arrhythmia (non-sinus rhythm on ECG)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lichen planopilaris activity index. Timepoint: Befor and after intervention. Method of measurement: Cheklist.;Standardized global photography. Timepoint: Befor and after intervention. Method of measurement: Based on scoring by two dermatologist.;Dermoscopy. Timepoint: Befor and after intervention. Method of measurement: Chcklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Shaghayegh dehghani
Esfahan University of Medical Sciences
Outcome results
None listed