Evaluation of the effect of intra-articular injection of dexamethasone and vitamin D compared to injection of dexamethasone alone on signs of knee osteoarthritis

The Effects of Intra-articular injection of dexamethasone and vitamin D compared to injection of just dexamethasone on signs of knee osteoarthritis with grade 2 and 3_ a randomized double-blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220526054993N1

Enrollment

154

Registered

2022-06-29

Start date

2022-08-21

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis with grade 2 and 3.

Interventions

Intervention 1: Intervention group: After randomization , 4 mg of dexamethasone plus one hundred and fifty thousand international units (IU) of vitamin D3 will be injected into the intra-articular spa

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 40 to 65 Bilateral knee osteoarthritis Having score 2 and 3 of KL system radiography Completion of informed consent form to enter the study

Exclusion criteria

Exclusion criteria: Presence of secondary cause for knee osteoarthritis Allergic history to dexamethasone or vitamin D History of diabetes or coagulopathy History or manifestation of joint infection or deformity

Design outcomes

Primary

Measure	Time frame
The score obtained in the WOMAC knee score to evaluate the degree of osteoarthritis. Timepoint: Before intervention and 1, 3, and 6 month after intervention. Method of measurement: WOMAC knee score.	—

Secondary

Measure	Time frame
The amount of analgesic consumption. Timepoint: Before intervention and 1, 3, and 6 mouths after intervention. Method of measurement: Questionnaire to assess the number of analgesics consumed per week.;Range of motion of the knee. Timepoint: Before intervention and 1, 3, and 6 mouths after intervention. Method of measurement: Clinical examination.;Joint pain. Timepoint: Before intervention and 1, 3, and 6 mouths after intervention. Method of measurement: The size of joint pain in millimeters on the scaled ruler.	—

Measure

Time frame

The amount of analgesic consumption. Timepoint: Before intervention and 1, 3, and 6 mouths after intervention. Method of measurement: Questionnaire to assess the number of analgesics consumed per week.;Range of motion of the knee. Timepoint: Before intervention and 1, 3, and 6 mouths after intervention. Method of measurement: Clinical examination.;Joint pain. Timepoint: Before intervention and 1, 3, and 6 mouths after intervention. Method of measurement: The size of joint pain in millimeters on the scaled ruler.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactArvin Najafi

Alborz University of Medical Science

parsmedicine@gmail.com+98 26 3442 7001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026