Evaluation of the effect of epinephrine doses in head and neck surgeries

Evaluation and comparison of the results and complications caused by the injection of 1/1,000,000, 1/500,000 and 1/200,000 dilutions of epinephrine in normal saline in the surgical field, on patients who are candidates for head and neck surgery, a clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220524054981N1

Enrollment

Registered

2022-07-25

Start date

2022-07-23

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optimal and optimal dilution of epinephrine, which, while reducing the amount of bleeding in the surgical field, has the least cardiovascular complications, including changes in blood pressure and cardiac arrhythmias.

Interventions

Intervention 1: Intervention group: Receive a dilution of 1 in 200,000 (Epinaline brand from Iran Hormon Company) to dilute epinephrine: First, we mix 1 cc of a 1/10000 vial of epinephrine with 9 cc

Eligibility

Sex/Gender

All

Age

16 Years to 70 Years

Inclusion criteria

Inclusion criteria: All patient ( non hypertensive ) that are candidate for head and neck surgeries aged 16_70

Exclusion criteria

Exclusion criteria: Age 70 Hypertention

Design outcomes

Primary

Measure	Time frame
Changes in blood pressure. Timepoint: During the surgery. Method of measurement: Monitoring.;Cardiac arrhythmias. Timepoint: During the surgery. Method of measurement: Monitoring.;The amount of bleeding during the operation. Timepoint: during the surgury. Method of measurement: Check list.;Number of times required for topical injection of epinephrine in the operation field. Timepoint: D???uring the surgery. Method of measurement: Check list.	—

Measure

Time frame

Changes in blood pressure. Timepoint: During the surgery. Method of measurement: Monitoring.;Cardiac arrhythmias. Timepoint: During the surgery. Method of measurement: Monitoring.;The amount of bleeding during the operation. Timepoint: during the surgury. Method of measurement: Check list.;Number of times required for topical injection of epinephrine in the operation field. Timepoint: D???uring the surgery. Method of measurement: Check list.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPantea zahedinia

Semnan University of Medical Sciences

panteaazahedinia@gmail.com+98 28 3323 2621

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026